Nucleato Tablet 250 Milligrams (Clarithromycin)

Adult dosage

Adults: The usual dose is 250mg (potency) of clarithromycin twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days to these patients. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily for 14 days together with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children aged 12 years and older: Same as adults Children under 12 years: Use clarithromycin dry syrup.

This medication should not be used in certain patients. Firstly, it should not be administered to individuals who are allergic to the additives included in this medication or who have had hypersensitivity reactions to similar classes of antibiotics. Furthermore, it should not be used in patients with severe heart-related conditions, significant renal and liver dysfunction, or in pregnant or breastfeeding women. This medication is excreted via the liver and kidneys, so caution is warranted for patients with compromised liver or kidney function. Patients with heart disease, the elderly, and those taking other antibiotics should also exercise caution when using this medication. Various side effects, including allergic reactions, gastrointestinal disturbances, respiratory difficulty, hematological abnormalities, neurological issues, and skin rashes can occur during treatment, and immediate consultation with a physician is necessary if symptoms arise. Particularly, serious allergic reactions or heart arrhythmias may require careful monitoring. Interactions with other drugs may occur, so it is essential to inform healthcare professionals of any concurrent medications. Pregnant or nursing women are advised to avoid this medication, and safety in pediatric populations has not been fully established. The elderly may require dosage adjustments due to potential elevation of blood concentration caused by decreased kidney function. In case of overdose, gastrointestinal disturbances or psychiatric symptoms may occur, and contact with a medical facility should be made immediately. This medication must be stored under appropriate conditions to maintain effectiveness and safety, and it should be taken under medical supervision when combined with other drugs.

Shock, anaphylactic symptoms, shortness of breath, convulsions, flushing, rash, itching, urticaria, skin redness, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, chest X-ray abnormalities, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, exacerbated acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbances, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized exanthematous pustulosis, muscle cramps, musculoskeletal stiffness, myopathy, increased serum creatinine, increased blood urea nitrogen, nephritis, phlebitis at the injection site, pain at the injection site, inflammation at the injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine color abnormalities, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration

This medication must be stored in a tightly sealed container to prevent exposure to air and moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius to ensure long-lasting efficacy and safety.

Appearance

Yellow rectangular film-coated tablet

Package unit

30 tablets, 100 tablets