New Glipfield M Tablet

Adult dose

This medication is administered 1-2 times a day just before or with meals. The initial dosage is glimepiride/metformin hydrochloride 2mg/500mg, and it can be gradually increased up to 8mg/2000mg based on blood glucose monitoring results. Generally, single-agent glimepiride shows minimal additional effects when doses beyond 4mg per day are used, although some patients may increase the dosage up to 6mg (or 8mg).

This medication can cause severe lactic acidosis or hypoglycemia, so it should be temporarily discontinued, especially when there is a rapid decline in kidney function or dehydration. It is contraindicated in patients with a renal function of less than 45 mL/min/1.73m², and elderly patients or those in situations where renal function may worsen should have their renal function regularly assessed. The risk of cardiovascular disease may increase during the administration of this medication, so it is essential to thoroughly explain the benefits and risks of treatment to the patient and observe them carefully. It should not be used in patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver dysfunction, pregnant or breastfeeding women, and patients with severe renal impairment. Patients at high risk for hypoglycemia, such as those with poor nutritional status, irregular eating habits, the elderly, and those with liver dysfunction, require special precautions while taking this medication. In the initial stages of treatment, gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.) may appear, which are mostly temporary, but if symptoms are severe, consultation with a physician is necessary. Allergic reactions, hematological abnormalities, and symptoms of vitamin B12 deficiency may occur, so regular blood tests and monitoring of vitamin B12 levels are recommended. This medication may interact with other drugs, so patients must inform healthcare professionals of any medications they are taking, particularly medications that may affect renal function. If pregnant or planning to become pregnant, it is safer to switch to insulin therapy instead of using this medication. In cases of overdose, hypoglycemia or lactic acidosis may occur, requiring immediate emergency treatment, and, if necessary, drug removal by hemodialysis may be needed. Care should be taken when driving or operating machinery as hypoglycemia or impaired agility may occur. The safety and efficacy of this medication have not been established in children and adolescents, so it is advisable not to use it in children under 10 years old. During storage, keep it in a tightly sealed container away from the reach of children, and do not transfer it to other containers.

Serious side effects

Urticaria, dyspnea, severe edema, chest tightness, hypotension, severe allergic reactions, severe lactic acidosis, acute renal failure, jaundice due to liver dysfunction, liver failure, severe skin adverse reactions (severe rash, blisters, skin peeling, pain in oral/eye mucosa), cardiovascular abnormalities (history of cardiac arrest, myocardial infarction), severe hypoglycemia (cerebral seizures, consciousness confusion, coma), paralysis, visual disturbances, severe neurological symptoms.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, anorexia, dyspepsia, constipation, abdominal pain), taste disorders, temporary visual impairment due to changes in blood sugar levels, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia, vitamin B12 decrease and deficiency, increased liver enzymes, liver function impairment, hepatitis, allergic vasculitis, skin photosensitivity, decreased serum sodium concentration.

This medication should be stored in a sealed container that prevents air or moisture from entering. Additionally, it is best to store the medication at room temperature, avoiding extremes of heat or cold, specifically between 1°C and 30°C.

Appearance

White rectangular film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle