Sevrek Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient. It may be taken with or without food. Osteoarthritis (degenerative arthritis) Take 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. Rheumatoid arthritis Take 100 mg or 200 mg of celecoxib per dose, twice daily. Ankylosing spondylitis (AS) Administer 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks at 400 mg daily, other treatment options should be considered. Acute pain and primary dysmenorrhea The recommended initial dose is 400 mg of celecoxib, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. Patients with hepatic impairment For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medicine should be discussed with a doctor or pharmacist if the patient regularly consumes more than three alcoholic beverages per day. This medicine may cause gastric bleeding, so caution is required. Additionally, this medicine may increase the risk of serious cardiovascular diseases such as thrombotic reactions, myocardial infarction, and stroke. Such risks may increase depending on the dosage and duration of treatment; thus, it is important to use the lowest effective dose for the shortest duration necessary. This medicine can cause serious gastrointestinal adverse reactions such as gastrointestinal perforation, ulcers, and bleeding. Special care is needed for elderly patients or those with a history of gastrointestinal diseases. If symptoms such as epigastric pain, indigestion, black stools, or vomiting of blood occur, immediate medical attention should be sought. This medicine should not be administered to individuals with certain allergy histories, severe liver or kidney impairment, active peptic ulcers, heart failure, and pregnant women. Patients with impaired liver or kidney function, asthma, hypertension, heart failure, edema, and diabetes should use this medicine with caution and require regular medical supervision. During the use of this medicine, side effects such as headache, dizziness, indigestion, vomiting, skin rash, hypertension, and edema may occur; thus, if unusual symptoms arise, immediate consultation with medical personnel is advised. This medicine is metabolized in the liver; hence, interactions may occur when co-administered with certain drugs. If there are any other medications being taken, the doctor or pharmacist should be informed. Women who are pregnant, planning pregnancy, or breastfeeding should not take this medicine, and if pregnancy is confirmed during use, it should be discontinued immediately and medical advice should be sought. Elderly patients may have decreased kidney and liver function, thus caution is needed when taking this medication, and dosage adjustments may be required. If this medicine is taken for a long period, regular blood tests and liver and kidney function tests should be conducted, and if any abnormalities are observed, administration may need to be stopped. In case of overdose, symptoms such as lethargy, drowsiness, nausea, vomiting, gastrointestinal bleeding, and acute kidney failure may appear, requiring immediate medical treatment. This medicine should be kept out of reach of children, and transferring to other containers may compromise quality.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusional state, dizziness, muscle rigidity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, pruritus, rash, urticaria, petechiae, angioedema, alopecia, bullous dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste alterations, albuminuria, cystitis, hematuria, dysuria, frequency of urination, nephrolithiasis, urinary incontinence, urinary tract infection, visual disturbances, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased N-acetyl-β-D-glucosaminidase (NAG), positive urinary hematuria, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, increased serum sodium, increased serum potassium, elevated blood urea nitrogen (BUN), increased creatine phosphokinase (CPK), diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, elevated non-protein nitrogen (NPN), increased creatinine levels, increased alkaline phosphatase, weight gain, loss of appetite, increased lactate dehydrogenase (LDH), hypoglycemia, hyponatremia, synovial sac, arthralgia, arthritis, skeletal abnormalities, myalgia, cervical muscle tension, synovitis, tendonitis, myositis, leg cramps, fractures, tendon rupture, pain in limbs, muscle stiffness, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, poliosis, contact dermatitis, injection site reactions, skin nodules, headache, leg cramps, sensory reduction, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, loss of taste, exacerbation of allergies, allergic reactions, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, loss of appetite, increased appetite, depression, neural hyperreactivity, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory tract infection, shingles, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infections, fungal infections, soft tissue infections, viral infections, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasms, chest pain, dysmenorrhea, menstrual disturbances, vaginal bleeding, vulvovaginitis, prostate disorders, ovarian cysts, auditory loss, ear anomalies, otalgia, hearing loss, hepatic dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen in urine, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, vasculitis, pulmonary embolism, interstitial pneumonia, photosensitive reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, generalized fixed drug eruption, fixed drug eruption, tubular interstitial nephritis, nephrotic syndrome, focal segmental glomerulosclerosis, female infertility, chest pain, thirst, ulcerative stomatitis, gastritis, allergies, low back pain, hyperlipidemia, hearing loss

This medicine should be stored in a tightly sealed container to prevent air and moisture intrusion. It is best to maintain a storage temperature between 15 to 30 degrees Celsius at room temperature to preserve its effectiveness and safety.

Appearance

A capsule filled with white to pale yellow powder, with a white cap and body.

Package unit

30 capsules/bottle, 100 capsules/bottle