Crezin Tablet 10mg (Rosuvastatin Calcium)

Adult dosage

This medication can be taken at any time of the day, regardless of meals. The initial dose is 5 mg once daily and can be adjusted to a maintenance dose as needed. The maintenance dose is usually 10 mg once daily, and most patients are controlled at this dose. The maintenance dose should be adjusted appropriately based on LDL cholesterol levels, treatment goals, and patient response at intervals of 4 weeks or more, with a maximum increase up to 20 mg per day.

Children's dosage

The usual dosage range for pediatric patients aged 10 to 17 years is once daily at 5 mg to 20 mg. The dosage should be adjusted individually based on the recommended treatment target and readjusted at intervals of 4 weeks or more.

This medication should not be used in patients with an allergy to specific ingredients. It should not be administered to individuals with severely impaired liver function or persistently elevated liver enzyme levels of unknown cause. Patients with muscle diseases or previous muscle issues should not take this medication. It is contraindicated for patients taking cyclosporine. Patients with very poor kidney function, particularly those with a creatinine clearance of less than 30 mL/min, should not use this medication. Pregnant or breastfeeding women, as well as women of childbearing age who do not use adequate contraceptive methods, should not take this medication. Women with a potential for pregnancy can only use this medication if they are very unlikely to conceive and have been adequately informed about the risks to the fetus. High doses (40 mg) are contraindicated in patients at high risk of muscle-related diseases. Risk factors include moderate renal impairment, hypothyroidism, family history or genetic history of muscle disorders, previous myotoxicity with similar medications, alcohol dependency, increased plasma concentration scenarios, Asian patients, and co-administration with fibrate drugs. This medication contains lactose, thus should not be administered to patients with lactose intolerance or related genetic disorders. Before taking this medication, liver function tests should be repeated to assess liver status, and patients with a history of high alcohol consumption or liver disease should exercise caution. Patients with hypercholesterolemia due to hypothyroidism or nephrotic syndrome should treat the underlying disease before administering this medication. Muscle-related side effects, such as myalgia, myopathy, and, rarely, rhabdomyolysis can occur, necessitating immediate communication with healthcare providers if any muscle-related symptoms arise. If there is a significant increase in creatine kinase levels alongside muscle-related symptoms, this medication should be discontinued. Creatine kinase levels can also increase after intense exercise or for other reasons, making caution necessary during testing. In acute severe conditions or severe diseases, this medication should be discontinued, and if severe muscle weakness or ocular muscle weakness occurs, administration should cease immediately. The risk of muscle toxicity may increase with co-administration of other medications, especially with high doses of fibrate drugs. Regular kidney function tests are recommended for patients taking high doses of this medication. Asian patients may experience increased body exposure to the drug, requiring careful dose adjustment. In pediatric patients, monitoring for growth and pubertal development is necessary, and attention should be given to elevated muscle enzyme levels post-exercise. Mild and transient side effects have been reported, with common symptoms including headache, dizziness, abdominal pain, constipation, myalgia, weakness, diarrhea, chest pain, cough, fatigue, numbness, paresthesia, loss of appetite, abdominal bloating, syncope, generalized pain, muscle cramps, gout, erectile dysfunction, joint pain, hematuria, thrombocytopenia, memory loss, peripheral neuropathy, polyneuropathy, depression, sleep disorders (including insomnia and nightmares), sexual dysfunction, gynecomastia, increased ALT, and AST.

Serious side effects

Allergic reactions including urticaria and angioedema, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), jaundice, hepatitis, severe swelling, chest tightness, difficulty breathing, respiratory distress, ocular muscle weakness, severe muscle weakness, immune-mediated necrotizing myopathy, rhabdomyolysis, acute renal failure, oliguria, sudden and severe headache, seizures, confusion.

Mild side effects

Headache, dizziness, constipation, nausea, abdominal pain, itching, rash, myalgia, weakness, diarrhea, chest pain, cough, fatigue, numbness, paresthesia, loss of appetite, abdominal bloating, syncope, generalized pain, muscle cramps, gout, erectile dysfunction, joint pain, hematuria, thrombocytopenia, memory loss, peripheral neuropathy, polyneuropathy, depression, sleep disorders (including insomnia and nightmares), sexual dysfunction, gynecomastia, increased ALT, increased AST

This medication should be stored in a tightly closed container to prevent exposure to air or moisture, and it is best to keep it at room temperature between 1 to 30 degrees Celsius. This will help maintain the drug's efficacy and safety.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle