Glimeam Tablet 2/500 mg

Adult dose

This medication is administered 1 to 2 times a day just before or with meals. The initial dose is 2 mg glimepiride/metformin hydrochloride 500 mg, which may be gradually increased based on blood sugar monitoring results, up to a maximum of 8 mg/2000 mg. When administering glimepiride as a monotherapy, additional efficacy is rarely seen with doses higher than 4 mg per day; however, some patients may be increased to 6 mg or 8 mg. Alternative therapy in combination therapy should be based on the dosing and administration of glimepiride and metformin hydrochloride currently being administered.

This medication can cause severe lactic acidosis or hypoglycemia; therefore, caution is necessary when used in patients with significantly impaired renal function. If there are symptoms of dehydration or if any medications that may affect renal function are being taken, this medication should be temporarily discontinued, and a physician should be consulted. In patients at risk for cardiovascular disease, this medication may increase cardiovascular mortality; thus, the risks and benefits should be carefully considered before and after treatment. Insulin-dependent diabetes patients, those with acute metabolic acidosis, severe liver or kidney dysfunction, pregnant or breastfeeding women, and patients with certain genetic lactose intolerance should not use this medication. Patients at high risk for hypoglycemia, malnourished individuals, those with irregular meals, vigorous exercise, alcohol users, the elderly, and patients with liver failure should use this medication with caution, paying particular attention to hypoglycemic symptoms at the start of treatment. Gastrointestinal disturbances (diarrhea, nausea, vomiting, etc.) are common while taking this medication, and if these symptoms are severe, a physician should be consulted. Rarely, skin rash, blood disorders, vitamin B12 deficiency, and liver function abnormalities may occur, so regular monitoring is necessary. This medication can interact with many other drugs, so it is important to inform your doctor or pharmacist if you are taking other medications. Caution is required when used with medications that may affect renal function or blood sugar control. It is recommended not to use this medication during pregnancy or breastfeeding, and if necessary, to switch to insulin therapy. Safety in children has not been sufficiently established, so this medication should be given with caution to pediatric patients. Elderly patients often experience reduced renal function; therefore, dosage adjustments and regular monitoring of renal function are necessary, and maximum dosages should be avoided. Overdose may lead to hypoglycemia and lactic acidosis, necessitating immediate medical treatment; if hypoglycemia is suspected, sugars should be quickly consumed, and in severe cases, emergency measures may be required. During this medication period, regular meals and exercise should be maintained, and regular checks of blood sugar, HbA1c, renal function, and hematological tests should be conducted. Additionally, excessive alcohol consumption should be avoided, and any unusual symptoms should prompt immediate consultation with healthcare providers. Caution is needed when driving or operating machinery due to the risk of hypoglycemia or other side effects.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, severe allergic reactions, peeling skin, severe skin reactions, yellowing of the skin or eyes (jaundice), liver abnormalities, sudden and severe headaches, seizures, confusion, paralysis, serious neurological symptoms, markedly decreased urine output, severe swelling of the whole body and increased blood pressure, severe edema or urinary abnormalities, hypoglycemia, lactic acidosis, thrombocytopenic purpura,

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), taste disturbances, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia, decreased vitamin B12, increased liver enzymes, hepatitis, liver function damage, allergic vasculitis, photosensitivity of the skin, decreased serum sodium concentration, hypothyroidism, magnesium deficiency in cases of diarrhea,

This medication should be stored in a tightly sealed container to prevent air from entering and kept at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the efficacy of the medication.

Appearance

White oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle