Simvam 20 mg Tablets (Simvastatin)

Adult dose

The recommended initial starting dose for reducing the risk of cardiovascular disease is 40 mg once daily. For treatment of hyperlipidemia, the typical initial starting dose is 20 mg taken once daily in the evening; mild to moderately elevated cholesterol patients may start with 10 mg. The dosage can vary from 5 to 40 mg taken once daily in the evening, adjusted according to initial LDL cholesterol levels and therapeutic goals.

Child dose

The recommended initial dose for pediatric patients (10 to 17 years) with heterozygous familial hypercholesterolemia is 10 mg once daily in the evening. The recommended dosage range is 10 to 40 mg per day, with a maximum dose of 40 mg.

This medication may cause muscle-related side effects such as myopathy and rhabdomyolysis, especially when taken at high doses, and therefore caution should be exercised. If unexplained muscle pain, tenderness, or weakness occur during treatment, the physician must be informed immediately. This drug is mainly metabolized in the liver, so patients with poor liver function should avoid or use it cautiously. Women who are pregnant, might become pregnant, or are nursing should not take this medication. When taken with certain specific medications, the blood concentration of this drug may increase, raising the risk of muscle-related side effects; therefore, it is necessary to discuss adjusting the dosage or using an alternative medication with a physician. Special caution should be taken when used in combination with strong CYP3A4 inhibitors, gemfibrozil, cyclosporine, danazol, certain antifungals, antibiotics, calcium channel blockers, etc. Elderly patients, women, patients with reduced renal or thyroid function, and those with a history of muscle diseases need to be more careful while taking this medication. It is advisable to have liver function tests and muscle-related tests regularly while on this drug. In case of overdose, seek medical attention immediately, and this medication should be kept out of the reach of children.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain, shortness of breath or difficulty breathing, asthma attack, respiratory difficulties accompanied by cough and fever, jaundice (yellowing of the skin or eyes), extreme fatigue, sudden and severe headache, lightning headache, seizures, confusion, vision problems, paralysis, urination

Mild side effects

• Abdominal pain
• fatigue
• constipation
• diarrhea
• dyspepsia
• bloating
• nausea
• headache
• upper respiratory infection
• atrial fibrillation

This drug must be stored in a closed container to prevent exposure to air or light, and it is important to store it at room temperature between 1 and 30 degrees Celsius. Proper storage helps to maintain the drug's effectiveness and safety.

Appearance

Brownish yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle