Clavoxine 625 mg (Amoxicillin·Clavulanate Potassium (4:1))

Adult dose

Adults and children 12 years and older or weighing 40 kg or more should take amoxicillin/clavulanate potassium at 250 mg/125 mg 3 times a day orally every 8 hours. In cases of severe and respiratory infections, the dose can be increased to 500 mg/125 mg once. For those with kidney dysfunction, dosage should be adjusted according to creatinine clearance. - Creatinine clearance 10-30 mL/min: 250 mg/125 mg every 12 hours

Child dose

Children under 12 years or weighing less than 40 kg should be administered at a reduced dosage similar to adults.

This medication is a penicillin and beta-lactam antibiotic and should not be administered to patients with severe allergic reactions. In particular, it may be dangerous for patients who have had hypersensitivity to this medication or similar drugs. Additionally, patients with infectious mononucleosis or lymphocytic leukemia may have a higher risk of rash when using this medication. For patients with decreased liver function or severe kidney disease, adjustments are necessary as drug concentration may increase, thus requiring careful administration. Caution is also necessary for those with allergic constitution, difficulty in oral intake, the elderly, and those in poor overall condition. This medication can affect the gastrointestinal system, causing various gastrointestinal symptoms such as diarrhea, abdominal pain, and vomiting; any abnormal symptoms should be reported to a physician immediately. Prolonged use can affect liver function, requiring liver function tests as jaundice or hepatitis symptoms may appear. Rarely, serious allergic reactions such as skin rash, urticaria, and anaphylaxis may occur, so if symptoms appear, administration should be stopped immediately. Changes in blood cell counts or bleeding tendencies may occur, requiring careful observation in patients at risk of bleeding. Rare occurrences of central nervous system symptoms such as anxiety, confusion, and seizures have been reported, and there is a risk of kidney damage in patients with impaired kidney function, necessitating regular assessments. While taking antibiotics, the intestinal bacterial balance may be disrupted, leading to other infections, so if symptoms occur, consult a physician. Pregnant women should avoid using it, especially in the first three months, and breastfeeding mothers should take care as side effects may occur in the infant. Use in children under 12 years or weighing less than 40 kg is not recommended due to limited experience. The elderly should use it cautiously, adjusting dosage and intervals due to increased risk of side effects.

Serious side effects

Urticaria, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blistering, skin peeling, pain in oral/ocular mucosa, shortness of breath or breathing difficulty, asthma attack, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and very severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, reduced urine output

Mild side effects

Diarrhea, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, abdominal distension, constipation, colonic pain, acid reflux, melena, dry mouth, acute pancreatitis, candidiasis, colitis, blood in stool, dry mouth, increased AST, ALT, ALP, LDH, elevated serum bilirubin, hepatitis, cholestatic jaundice, itching, erythema multiforme, mucocutaneous syndrome, toxic epidermal necrolysis, vesicular exfoliative dermatitis, acute generalized exanthematous pustulosis

This medication is contained in a closed container to protect it from moisture and air. It should be stored in a cool place between 1 degree and 25 degrees Celsius. This way, the effectiveness of the medication can be maintained longer.

Appearance

White or almost white oval film-coated tablets

Package unit

40 tablets/box [(4 tablets/PTP X 10)]