Claoxin 375 mg (Amoxicillin-Clavulanate Potassium (2:1))

Adult dose

Adults and children aged 12 years or older, or weighing 40 kg or more, should take 250 mg/125 mg of amoxicillin/clavulanate potassium three times daily orally every 8 hours. In severe and respiratory infections, the dosage may be increased to 500 mg/125 mg. For those with renal impairment, dosage adjustments should be made based on creatinine clearance. - For creatinine clearance of 30 mL/min or more: dosage adjustment is not necessary.

Child dose

Children under 12 years of age or weighing less than 40 kg should have their dosage reduced similarly to adults in cases of renal impairment.

This medication is a penicillin antibiotic and should not be used by individuals allergic to specific components. Patients with a history of hypersensitivity to beta-lactam drugs, or those with infectious mononucleosis or lymphocytic leukemia, have a higher risk of side effects such as rash and should avoid it. Those with liver issues or moderate to severe kidney impairment need to exercise caution while using this medication and may need to adjust dosing intervals. Additionally, patients with allergic tendencies, elderly patients, or those in poor general condition should use it with care. During use, gastrointestinal symptoms such as diarrhea, abdominal pain, and vomiting may occur, and rarely severe hepatitis, skin rashes, or anaphylaxis may develop, so any unusual symptoms should prompt immediate consultation with a physician. Regular monitoring of liver function, kidney function, and blood status is essential for prolonged use, especially if used for more than 14 days. This medication may interact with other drugs, so patients must inform their healthcare provider of any other medications they are taking. Pregnant or breastfeeding women should consult with a doctor before using this medication, as side effects may occur in the infant during breastfeeding. This medication is not recommended for children, particularly those under 12 years of age or weighing less than 40 kg. In case of overdose, gastrointestinal symptoms or central nervous system disturbances may occur, requiring immediate medical attention. Finally, this medication should be stored in a dry place below 25 degrees Celsius, and caution should be exercised not to arbitrarily extend or discontinue the treatment period without a doctor's instructions.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, paleness, anaphylaxis, Stevens-Johnson syndrome (skin and mucous membrane toxicity), shock, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, respiratory distress, asthma attack, respiratory abnormalities with coughing and fever, yellowing of the skin or eyes (jaundice), general lethargy, sudden and severe headache, thunderclap headache, seizures

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, black hairy tongue, nausea, vomiting, loss of appetite, abdominal pain, abdominal distension, constipation, colonic pain, hyperacidity, soft stools, dry mouth, candidiasis, antibiotic-associated colitis, elevated AST, ALT, ALP, LDH, serum bilirubin, hepatitis, cholestatic jaundice, itching, erythema multiforme, angioedema, serum sickness-like syndrome, hypersensitivity vasculitis, acute generalized exanthematous pustulosis

This medication is contained in a special sealed container to protect it from moisture and air. Additionally, it should be stored at a cool temperature between 1 to 25 degrees Celsius to maintain its effectiveness.

Appearance

White or almost white oval film-coated tablet

Package unit

100 tablets/box [(10 tablets/PTP*10)]