Aicleo Tablets (Clopidogrel Bisulfate)

Adult dosage

○ Adults 1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer 75 mg of clopidogrel orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), start treatment with a loading dose of 300 mg of this drug once daily on the day treatment is initiated, followed by a maintenance dose of 75 mg once daily orally. In this case, aspirin 75 ～ 325 mg should be administered concomitantly with this drug once daily. 3. For patients with atrial fibrillation, administer 75 mg of this drug orally once daily. In this case, aspirin 75 ～ 100 mg should be administered concomitantly with this drug once daily. ○ Patients with renal impairment: Treatment experience in patients with renal impairment is limited. ○ Patients with hepatic impairment: Treatment experience in patients with moderate hepatic disease with a bleeding diathesis is limited. This drug may be administered regardless of food intake.

This drug inhibits platelet aggregation to prevent blood clot formation. It must be activated in the liver to be effective, so caution is needed for patients with genetic impairment of certain enzymes as this may reduce the drug's effectiveness. Patients at risk of bleeding, patients with severely impaired liver function, nursing women, and patients with specific lactose metabolism disorders should not use this medication. Patients at high risk of bleeding, those with liver or kidney disorders, and elderly patients should use this drug cautiously; it is necessary to discontinue use 5 to 7 days before a scheduled surgery. This medication can cause bleeding; hence, if any bleeding symptoms occur, one should immediately inform a physician and undergo examination. Moreover, this drug may increase the risk of bleeding when used in conjunction with other medications that pose a bleeding risk, so caution is warranted during combined therapy. During pregnancy, the risk to the fetus is low, but the risk of bleeding during delivery suggests a recommendation to discontinue medication before childbirth. If nursing, consider stopping breastfeeding or discontinuing the medication due to the potential for the drug to be excreted in breast milk. The safety and efficacy of this drug in children have not been established, and elderly patients may have a higher risk of bleeding due to decreased physiological functions, necessitating dosage adjustments and careful monitoring. In cases of overdose, bleeding time may be prolonged, and platelet transfusion may reverse the drug's effect if needed. This drug must be kept out of reach of children and should not be transferred to another container.

Hemorrhage, gastrointestinal bleeding, purpura, contusion, hematoma, epistaxis, hematuria, intraocular hemorrhage, intracranial hemorrhage, neutropenia, agranulocytosis, aplastic anemia, thrombocytopenia, abdominal pain, dyspepsia, diarrhea, nausea, rash, pruritus, chest pain, accidental injury, influenza-like illness, pain, fatigue, edema, hypertension, headache, dizziness, depression, dyspnea, rhinitis, bronchitis, cough, urinary tract infection, decreased motor function, tremor, vocal dysfunction, abnormal gait, hyperactivity, ataxia, sensory disturbances, constipation, vomiting, ulcer, stomach pain, loss of appetite, hiccups, thirst, dysphagia, tongue disorders, insomnia, depression, forgetfulness, anxiety, confusion, abnormal thoughts, abnormal behavior, rigidity, weight loss, weight gain, facial flushing, weakness, fainting, purpura, melena, hematoma, hemoptysis, muscle hemorrhage, gingival bleeding, anemia, pneumonia, sinusitis, visual disturbance, visual field defect, dry eye syndrome, transient blindness, congestion, tinnitus, taste disorder, urinary dysfunction, polyuria, non-protein nitrogen increase, uremia, increased blood urea nitrogen, hypoglycemia, hyperuricemia, increased liver enzymes, ALT elevation, abnormal liver function, leg edema, arrhythmia, bradycardia, palpitations, contact dermatitis, gynecomastia, elevated prostate-specific antigen, cholecystitis, hematemesis, spinal hematoma, allergic symptoms, ischemic necrosis, gastritis, hemorrhagic gastroenteritis, duodenal ulcer, gastric ulcer, perforated gastric ulcer, upper gastrointestinal tract ulcer bleeding, bloating, hyperbilirubinemia, infectious hepatitis, fatty liver, hemorrhagic arthropathy, hematuria, hemoptysis, retroperitoneal hemorrhage, surgical wound bleeding, pulmonary hemorrhage, serum sickness, confusion, hallucination, taste loss, vasculitis, hypotension, bronchospasm, interstitial pneumonia, eosinophilic pneumonia, colitis, pancreatitis, stomatitis, hepatitis, acute liver failure, petechial eruptions, erythematous skin rash, urticaria, itching, angioedema, vesicular dermatitis, drug rash, eczema, lichen planus, arthralgia, arthritis, myalgia, glomerulonephritis, gynecomastia, fever

Store this medication in a tightly sealed container to avoid exposure to air or moisture. Additionally, it is best to store it at room temperature between 1°C to 30°C.

Appearance

Pink, round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle