Achtidrol-B-CGA Solution

Adult administration

Select the appropriate alkaline solution for artificial kidney dialysis based on the patient’s condition and the type of artificial kidney being used and dilute it with this solution and purified water.

This drug should be used cautiously in patients with severe liver dysfunction or severe diabetes due to problems in acetate metabolism. If acetic acid is not properly metabolized, it may lead to supressed heart function or peripheral vascular dilation, causing symptoms of low blood pressure. Patients taking digitalis glycosides should be careful as the serum potassium levels may decrease, leading to symptoms of digitalis toxicity when using this drug. During the use of this drug, changes in blood sugar levels should be monitored, and if symptoms of hypoglycemia or hyperglycemia occur, appropriate treatment should be sought immediately. Particularly, blood sugar levels can fluctuate rapidly during or after dialysis, requiring thorough blood sugar management. Also, due to thirst, fluid intake may increase, leading to weight gain or elevated blood pressure; therefore, fluid management and weight control may be necessary as required. Bone complications such as osteoporosis, osteomalacia, or fibrous osteitis may occur due to disturbances in calcium metabolism, and heterotopic calcification may develop, indicating the need for regular check-ups and appropriate treatment. Dialysis disequilibrium syndrome may present symptoms such as headaches, nausea, vomiting, convulsions, and altered consciousness, necessitating adjustments in dialysis efficiency upon symptom occurrence. It can affect the cardiovascular system, potentially causing low blood pressure or shock symptoms; therefore, dialysis should be halted or its efficiency reduced, and appropriate treatment should be pursued when symptoms appear. Additionally, there may be rare instances of elevated blood pressure necessitating antihypertensive medication or changes in dialysis solution. This drug is used for hemodialysis in chronic renal failure patients and serves as a dialysis solution containing sodium bicarbonate used when the high concentration of acetate in the dialysis solution is insufficient for the improvement of metabolic acidosis or when managing complications due to the disequilibrium syndrome or low blood pressure is difficult. It is used in cases where blood sugar control is needed in dialysis solutions containing glucose, and low potassium, calcium, and magnesium concentration dialysis solutions are appropriate for situations where hyperkalemia, hypermagnesemia, or hypercalcemia are concerns. It is essential to regularly check electrolytes, acid-base balance, blood sugar, etc., through blood tests. The safety during pregnancy has not been established, so it should only be used when the benefits outweigh the risks for pregnant women or those capable of becoming pregnant. Safety in children has not been established; therefore, it must be used cautiously in pediatric patients. In elderly patients, there is a risk of bone complications necessitating regular clinical examination and appropriate management such as administration of active vitamin D3 as needed. The diluent for dialysis must utilize strictly purified water, and caution must be taken regarding the risk of bleeding due to anticoagulant use and the integrity of the dialysis membrane. When preparing, do not use the electrolyte solution for artificial kidney dialysis alone or sodium bicarbonate solution, and prepare accurately with the designated diluent. If concentrations are too high or low, serious symptoms such as headache, palpitations, abnormal blood pressure, or altered consciousness may occur, requiring careful attention. The electrolyte concentration and pH of the dialysis solution must be verified before use, and it should be used immediately after dilution. If more than 2 hours have passed at 38 degrees Celsius after mixing, insoluble particles may develop and should not be used. This drug should not be used for injection or peritoneal perfusion, and maintaining serum osmotic balance during dialysis is essential. When used, adjusting the temperature to body temperature is safe.

Serious side effects

• Hypotension
• shock symptoms
• altered consciousness
• convulsions

Mild side effects

Hypoglycemia, hyperglycemia, weight gain, tendencies of elevated blood pressure, osteoporosis, osteomalacia, fibrous osteitis, heterotopic calcification, headache, nausea, vomiting, convulsions, altered consciousness, discomfort, lethargy, elevated blood pressure, limb weakness, general malaise, chest discomfort, altered consciousness due to inaccurate concentration

This drug should be stored in a sealed container to prevent exposure to air, and it is best kept at a temperature between 1 and 30 degrees Celsius. This storage condition helps maintain the drug's efficacy and prevent deterioration.

Appearance

A colorless to pale yellow transparent liquid with a salty taste

Package unit

5 liters/container, 10 liters/container, 5.5 liters/container