Nizatidine Tablet 150mg (Nizatidine)

Adult dose

1. Treatment of active gastric and duodenal ulcers Adults: Administer nizatidine 300mg once daily at bedtime, or 150mg twice daily, orally in the morning and evening. Most ulcers heal within 4 weeks, but treatment may be continued for up to 8 weeks if necessary. In cases of active gastric ulcer, malignancy must be ruled out before treatment. 2. Prevention of duodenal ulcer recurrence Adults: After healing of a duodenal ulcer, administer 150mg orally once daily at bedtime. Treatment may be continued for up to 1 year; results of longer-term treatment are not known. 3. Gastroesophageal reflux disease Adults: Administer 150mg orally twice daily in the morning and evening. Treatment may be continued for up to 12 weeks. 4. Improvement of gastric mucosal lesions Adults: Administer 150mg orally twice daily in the morning and evening for 2 weeks. 5. Dosage adjustment for patients with severe renal impairment The dosage for patients with renal impairment should be reduced and adjusted as follows. Active duodenal ulcer, gastroesophageal reflux disease (GERD), benign gastric ulcer: Creatinine clearance 20~50 ml/min — 150mg/day Active duodenal ulcer, gastroesophageal reflux disease (GERD), benign gastric ulcer: Creatinine clearance < 20 ml/min — 150mg every other day Maintenance therapy: Creatinine clearance 20~50 ml/min — 150mg every other day Maintenance therapy: Creatinine clearance < 20 ml/min — 150mg every 3 days Some older adults may have creatinine clearance below 50mL/min. Based on pharmacokinetic data in patients with renal impairment, the dosage should also be reduced in these patients according to the degree of renal impairment. The clinical impact of this dosage reduction in patients with renal impairment has not been evaluated.

This medication should not be used in certain patients. Patients who have had allergic reactions to this medication or other H2-receptor antagonists should not take this medication. Allergic reactions may manifest as skin rashes, itching, or difficulty breathing. Additionally, patients with hypersensitivity to the drug, impaired liver function, or reduced kidney function should use this medication with caution. In particular, patients with poor kidney function may need to reduce the dosage or increase the dosing interval, as the drug concentration may remain in the body longer. While taking this medication, various side effects may occur, such as skin rashes, itching, difficulty breathing, various blood abnormalities, gastrointestinal disturbances, liver function abnormalities, mental confusion, headaches, dizziness, irregular heartbeat, symptoms of gynecomastia, and skin rashes. If any of these symptoms occur, discontinue use immediately and consult a healthcare professional. This medication may mask symptoms of stomach cancer, so it should only be used after confirming that it is not cancer. Since it is primarily excreted through the kidneys, patients with reduced kidney function may need dosage adjustments, and careful monitoring of therapeutic effects and side effects is required. Women who are pregnant or may become pregnant should only use this medication if the benefits outweigh the risks. Breastfeeding women should also only use it when necessary, and safety in pediatric patients has not been established. Elderly patients may have impaired kidney function, so it is advisable to have kidney function tests before taking the medication and to closely monitor renal condition during use. In cases of overdose, symptoms such as vomiting, diarrhea, and pupil constriction may occur, and treatment such as activated charcoal administration or gastric lavage may be necessary. This medication is not effectively removed by hemodialysis, so caution is required. This medication has relatively few interactions with other drugs; however, care should be taken when taken with high doses of aspirin as salicylate levels may increase. Finally, this medication is reported to have a low risk of carcinogenicity or genotoxicity even with long-term high-dose administration, but the effects on the fetus during pregnancy have not been thoroughly studied, requiring careful use.

• Rash
• itching
• bronchial asthma
• laryngeal edema
• symptoms of anaphylaxis
• anemia
• leukopenia
• neutrophilia
• thrombocytopenic purpura
• constipation

This medication should be stored in a tightly closed container to protect it from air and moisture. It is best to maintain the storage temperature between 15 degrees and 30 degrees.

Appearance

Yellow circular film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle