HCD Solv BCA Solution

Adult administration

Depending on the patient's condition and the type of artificial kidney being used, an appropriate basic solution for artificial kidney dialysis should be selected and diluted with this solution and purified water.

This medication should be used cautiously in patients with severe hepatic impairment or severe diabetes who have difficulty metabolizing acetate. If acetate is not properly degraded, it can suppress heart function and cause peripheral vasodilation leading to hypotension. Patients taking digitalis glycosides should be cautious as serum potassium levels may drop, leading to the risk of digitalis toxicity. Using this on patients with elevated serum calcium and phosphorus levels before dialysis can lead to abnormal calcium deposition known as metastatic calcification. Patients who have insufficient caloric intake or dietary restrictions due to diabetes, or who are taking hypoglycemic medications should be careful as there is a risk of hypoglycemia. If symptoms of hypoglycemia occur while using this drug, immediate action such as administering glucose injection or consuming sugar is necessary. Since serum calcium levels can rise, if hypercalcemia is detected, the dialysate should be changed to one with lower calcium levels. Bone-related complications such as osteoporosis, osteomalacia, and fibrous osteitis can occur, so these symptoms should be treated with active vitamin D3 preparations. If metastatic calcification, an abnormal calcium deposit, occurs, measures should be taken to maintain serum phosphorus levels within the normal range by administering phosphorus binders. Symptoms such as headache, nausea, vomiting, convulsions, and altered consciousness during dialysis may indicate dialysis disequilibrium syndrome, requiring appropriate measures such as reducing dialysis efficiency. There may be issues with circulation causing hypotension or shock due to rapid blood volume loss, necessitating stopping dialysis or reducing efficiency and administering fluids and blood pressure-raising agents. Rarely, blood pressure may rise during treatment, requiring measures such as administering antihypertensives or changing to acetate-based dialysate. This medication is used for hemodialysis in patients with chronic renal failure and is utilized when metabolic acidosis is difficult to improve with high-acetate dialysate, or when dialysis management is challenging due to disequilibrium syndrome or hypotension. It can be used as a substitute for glucose-containing dialysate in patients with abnormal glucose metabolism leading to hyperglycemia. Regular blood tests to monitor electrolytes, acid-base balance, and blood sugar are recommended for safety. Safety in pregnancy has not been established; therefore, pregnant women or those possibly pregnant should only use it if the benefits of treatment outweigh the risks. Safety for children has also not been established, so caution is necessary. Elderly patients should also use it cautiously, just like other patients, and if used for a long time, regular check-ups and administration of vitamin D3 preparations are recommended to prevent bone complications. The dialysate diluent should be purified water to prevent contamination, and care should be taken to avoid membrane rupture and bleeding tendencies. During preparation, the electrolyte solution for artificial kidney dialysis and sodium bicarbonate solution should not be used independently and should be prepared accurately with designated diluents. Inaccurate dilution concentrations can lead to headaches, palpitations, blood pressure abnormalities, and consciousness disturbances, so caution is needed. Before use, the electrolyte concentration, osmotic pressure, pH of the dialysate must be checked, and any dialysate that has been mixed for more than 2 hours must not be used. Furthermore, this medication should not be used for injection or peritoneal dialysis, and the dialysate should be maintained at body temperature during use.

Serious side effects

Altered consciousness, consciousness disturbances

Mild side effects

Hypoglycemia, hypercalcemia, bone complications such as osteoporosis, osteomalacia, fibrous osteitis due to calcium metabolism abnormalities, symptoms of dialysis disequilibrium syndrome (headache, nausea, vomiting, convulsions, malaise, fatigue), increased blood pressure, palpitations, limb numbness, general malaise, chest discomfort

This medication should be stored in a sealed container to prevent air or moisture from entering, and the storage temperature should be maintained between 1 and 30 degrees Celsius at room temperature. Proper storage will help maintain the drug's efficacy.

Appearance

Transparent liquid with a colorless to pale yellow appearance and a salty taste

Package unit

5.5 liters/container, 10 liters/container