Clarithromycin 500 mg Tablet

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily; for severe infections, administer 500mg (potency) twice daily. The usual treatment period is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days to these patients. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In such cases, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) per dose three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children aged 12 years and older: Same as adults. Children under 12 years: Use clarithromycin dry syrup.

This drug should not be used in patients with known allergies to any of its components or those who have experienced hypersensitivity reactions to macrolide antibiotics. Care should be taken when combined with some medications that may affect heart rhythm, as serious side effects such as cardiac arrhythmias may occur. It is contraindicated or should be used cautiously in patients with severely impaired liver or kidney function, pregnant or breastfeeding women. This drug can cause various side effects, so if any unusual symptoms occur, it is essential to consult a physician immediately. Special attention should be given to the potential for allergic reactions, gastrointestinal disturbances, liver function abnormalities, kidney issues, and central nervous system symptoms. Due to numerous drug interactions, it is crucial to inform healthcare providers of all medications being taken to avoid side effects or diminished effects due to changes in drug concentration. This medication should be taken only for the necessary duration to prevent the development of resistant bacteria, and regular check-ups are required for long-term use. Caution is needed when driving or operating machinery as dizziness or confusion may occur. Special attention is required for children, the elderly, and patients with weakened immune systems, as dosage adjustments may be needed. Overdose can lead to gastrointestinal symptoms or psychological symptoms, necessitating immediate emergency treatment. Store in a cool place away from direct sunlight at room temperature and do not refrigerate.

shock, anaphylactic symptoms, dyspnea, convulsion, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste alteration, loss of appetite, constipation, discoloration of feces, pseudomembranous colitis, hemorrhagic colitis, fever, cough, chest X-ray abnormality, eosinophilia, eosinophilic pulmonary infiltrate, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, tremors, paresthesia, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, stomatitis, oral mucositis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, altered taste, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized exanthematous pustulosis (AGEP), muscle spasms, musculoskeletal stiffness, myopathy, increased serum creatinine, elevated blood urea nitrogen (BUN), nephritis, venous thrombophlebitis at the injection site, pain at the injection site, inflammation at the injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, elevated lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urine color, vasodilation, cardiac arrest, atrial fibrillation, QT prolongation on ECG, ectopic beats, palpitations, ventricular fibrillation, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura

This medicine is sensitive to light and should be stored in a container that blocks light. Additionally, to maintain its efficacy, store it at a temperature between 15 and 30 degrees Celsius.

Appearance

Yellow rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle