Jovatorin Tablets 10/10 mg (Ezetimibe/Simvastatin)

Adult dose

This drug is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10 mg to 10/40 mg per day, with a generally recommended starting dose of 10/20 mg per day. Patients with less need for LDL cholesterol reduction may start at 10/10 mg per day. After starting treatment or adjusting the dose, blood lipid levels should be checked at intervals of more than four weeks.

This drug is used to lower blood cholesterol levels. Symptoms such as muscle pain or weakness may occur during treatment, so if these symptoms appear, you must inform your doctor immediately. Particularly, the risk of muscle-related side effects may increase when taken at high doses or with certain other medications. This drug may affect liver function, so it should not be taken by individuals with liver disease or abnormal liver function test results. Women who are pregnant or breastfeeding should not take this drug, and women who may become pregnant must confirm their pregnancy status before taking it. Additionally, the risk of side effects may increase when taken with certain enzyme-inhibiting drugs, so you should inform your doctor or pharmacist of any medications you are taking. Caution is needed for elderly patients and children, especially those under 10 years old, as safety has not been fully established. Regular blood tests to check liver function and muscle enzyme levels are recommended during treatment. In case of overdose, general treatment for symptoms will be provided as there is no specific antidote. During treatment with this medication, grapefruit juice and certain drug combinations should be avoided, and healthcare professionals should be informed of this medication when starting new drugs.

Serious side effects

Hives, severe swelling (edema), anaphylaxis, angioedema, severe allergic reactions, severe skin adverse reactions (including rash, mucocutaneous syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Lyell's syndrome, erythema multiforme), myopathy, rhabdomyolysis, liver abnormalities (hepatitis, liver dysfunction, jaundice, acute liver necrosis, liver failure), respiratory issues (dyspnea, interstitial lung disease).

Mild side effects

Headache, diarrhea, myalgia, limb pain, influenza, upper respiratory infection, fatigue, abdominal pain, nausea, constipation, dyspepsia, flatulence, itching, rash, elevated creatine phosphokinase (CPK) levels, weight loss, edema, thirst, facial swelling, syncope, paresthesia, insomnia, gastritis, atrophic gastritis, mucus stools, irritable bowel syndrome, sore throat, nocturia, hematuria, alopecia, gynecomastia, decreased libido, sexual dysfunction, cataracts.

This medication is sensitive to air and moisture, so it must be stored in a tightly closed container. Additionally, it is recommended to store the medication at room temperature, between 1 to 30 degrees Celsius, avoiding excessively high or low temperatures.

Appearance

White to off-white, biconvex, rectangular tablets

Package unit

30 Tablets (10 Tablets/Blister Package X 3)