Febuxostat 80 Milligrams (Febuxostat)

Adult dosage

1. Adults Administer 40 mg or 80 mg of this medicine once daily, with or without food. This medicine acts very rapidly; therefore, recheck the serum uric acid level after 2 weeks. The treatment goal is to lower and maintain the serum uric acid level below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dose adjustment is required in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30 mL/min). 3. Patients with hepatic impairment No special dose adjustment is required in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh Class C).

This medication may increase the risk of cardiovascular mortality when administered to patients with cardiovascular disease; therefore, alternative treatments should be considered for these patients. Patients with an allergy to the active ingredient or excipients of this medication, those taking mercaptopurine or azathioprine, and those with lactose intolerance or specific genetic metabolic disorders should not take this medication. Patients with a history of liver disease or thyroid dysfunction, ischemic heart disease, congestive heart failure, and organ transplant recipients must use this medication cautiously, and especially should undergo regular liver function tests. Taking this medication may result in various side effects such as liver function abnormalities, diarrhea, headache, rash, fatigue, joint pain, dizziness, etc., so any symptoms that arise should be discussed with healthcare providers. Acute gout attacks should not result in the initiation of this medication, and during the initial administration, it is essential to consider appropriate preventive treatment as gout attacks may worsen. This medication can cause drowsiness and dizziness, so caution should be taken when driving or operating hazardous machinery. If symptoms or side effects related to cardiovascular disorders occur, healthcare providers should be notified immediately, and if signs of decreased liver function appear (e.g., weakness, loss of appetite, jaundice), the medication should be stopped immediately, and testing should be performed. This medication is not recommended for women who are pregnant or breastfeeding, and there is no experience using it in children under 18 years old, so it should not be administered to them. Additionally, this medication may interact with specific drugs, and it is crucial to inform healthcare providers if other medications are being taken. In case of overdose, no specific antidote exists, so treatment should be symptom-based, and it should be stored out of reach of children.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, myalgia, pruritus, dyspnea, vomiting, arthralgia, rash, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, abnormal electrocardiogram, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, flatulence, increased bowel frequency, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, passage of blood in stool, oral ulcer, pancreatitis, gastric ulcer, vomiting, weakness, chest pain, chest discomfort, edema, mood disorders, gait disturbance, influenza-like symptoms, mass, pain, thirst, cholecystitis, diabetes insipidus, hepatic steatosis, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes mellitus, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, arthric rigidity, joint swelling, muscle cramps, muscle fasciculation, muscle spasm, muscle weakness, musculoskeletal pain, muscular rigidity, taste changes, balance disorder, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, olfactory dysfunction, heat stroke, drowsiness, mental disorder, migraine, sensory disturbances, sleepiness, transient ischemic attack, tremors, agitation, anxiety, depression, insomnia, excitability, decreased libido, neurogenic sensitivity, panic attack, personality changes, hematuria, nephrolithiasis, increased frequency of urination, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, paranasal sinus hypersecretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin eruptions, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin exfoliation, petechial hemorrhage, photosensitivity, pruritus, purpura, skin discoloration, changes in pigmentation, skin lesions, axillary osmidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, prolonged activated partial thromboplastin time, increased creatinine, decreased bicarbonate, increased sodium, abnormal EEG, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea nitrogen, increased blood urea nitrogen to creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocytes, decreased neutrophils, increased leukocytes, decreased leukocytes, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive leukocytes in urine, positive protein in urine, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, severe allergic reaction, hypersensitivity reaction, eosinophilia, drug reactions accompanied by systemic symptoms, fever, hematological disorders, renal disorders, hepatic disorders, hepatic failure, jaundice, hepatic impairment, liver dysfunction, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly closed container to avoid exposure to air or moisture, and it is safest to keep it at room temperature between 1 degree and 30 degrees Celsius. This storage will help maintain the efficacy of the medication.

Appearance

Pale yellow to yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle