Estene Capsule 300 mg (Erdosteine)

Adult dose

Adults: The usual dose is 300 mg of erdosteine orally 2–3 times daily. When administered for acute respiratory disease, do not administer continuously for more than 10 days.

This medication should not be used in certain patients. Patients allergic to this medicine or its ingredients should not take it. Patients with liver cirrhosis or cystathionine synthase deficiency should avoid this medication, as its metabolites may interfere with methionine metabolism. Patients with peptic ulcers are also advised not to use this medicine. Patients with severe renal impairment, especially those with a creatinine clearance of less than 25 mL/min, should not take this medication. Patients with severe liver impairment should also refrain from using this medication. Mild to moderate liver impairment patients should exercise caution when using this medication. This medicine should not be taken in doses exceeding 300 mg per day. Additionally, it contains a pigment called yellow No. 5, so patients who are allergic to or have had hypersensitivity reactions to this ingredient should take this medication with caution. In cases of overdose, symptoms such as sweating, dizziness, and facial flushing may occur. Headaches may arise while taking this medication. Cold symptoms or respiratory distress may also occur, so caution is advised. Gastrointestinal symptoms may include taste disturbances, nausea, vomiting, diarrhea, upper abdominal pain, abdominal pain, and heartburn. Skin allergic reactions such as urticaria, erythema, and eczema may appear. Post-marketing surveillance in Korea has reported fatigue, indigestion, abdominal pain, gastrointestinal disorders, diarrhea, vomiting, headaches, acid reflux symptoms, erythema nodosum, palpitations, facial swelling, general edema, itching, weakness, confusion, rashes, although the relationship with this medication is not clear. As this medication is an expectorant, taking it with cough syrup may increase the risk of bronchial infection due to difficulty in expelling phlegm from the bronchial passages and may result in bronchospasm; thus, caution should be observed. Women who are pregnant or may become pregnant, as well as breastfeeding women, are advised not to take this medication as its safety has not been established. This medicine should be stored out of reach of children. Additionally, transferring the medication to another container could lead to accidents or negatively affect the quality of the medicine, so care should be taken.

• sweating
• dizziness
• flushing
• headache
• cold
• shortness of breath
• taste disturbances
• nausea
• vomiting
• diarrhea

Drug interactions

This medication may interact when taken with cough medications, so consultation with a doctor or pharmacist is recommended.

This medication must be stored in a tightly sealed container to avoid exposure to air or moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. This way, the efficacy of the medication can be safely preserved.

Appearance

A hard capsule with a green upper part and a yellowish lower part containing a white powder.

Package unit

30 capsules/bottle, 500 capsules/bottle