Jinset Tablet 250mg (Cefuroxime Axetil)

Adult dose

Administration: For optimal absorption, take after meals. 3) Patients with renal impairment Cefuroxime is excreted primarily by the kidneys. To compensate for delayed excretion in patients with significantly impaired renal function, reduction of the cefuroxime dosage as follows is recommended. Creatinine clearance ≥ 30 mL/min/1.73m2, T1/2 (hours) 1.4 - 2.4: No dosage adjustment necessary (standard dosage: 125mg-500mg per dose, twice daily) Creatinine clearance 10 - 29 mL/min/1.73m2, T1/2 (hours) 4.6: Administer the standard single dose every 24 hours Creatinine clearance < 10 mL/min/1.73m2, T1/2 (hours) 16.8: Administer the standard single dose every 48 hours Patients undergoing hemodialysis, T1/2 (hours) 2 - 4: Administer an additional standard single dose at the end of each dialysis session For the treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), this medicine should be administered for 7~10 days.

Child dose

Age 12 years and older: Most infections — administer 250mg per dose, twice daily. Age 12 years and older: Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by organisms with reduced susceptibility — administer 500mg per dose, twice daily. Age 12 years and older: Urinary tract infections — administer 250mg per dose, twice daily. Age 12 years and older: Uncomplicated gonorrhea — administer 1g as a single dose. Age 12 years and older: Lyme disease — administer 500mg per dose, twice daily, for 14 days (10~21 days). Under 12 years: Most infections — administer 125mg per dose, twice daily. Age 2 years and older: Otitis media, severe infections — administer 250mg per dose, twice daily. Under 12 years: Lyme disease — administer 250mg per dose, twice daily, for 14 days (10~21 days). There is insufficient experience with use in infants under 3 months of age. This medicine must not be divided and is therefore not appropriate for treating patients who cannot swallow tablets, such as young infants and children.

This medication should not be used in patients with a history of allergy to cephalosporin antibiotics. Caution is necessary when administering this medication to patients with a history of allergy to penicillin or other beta-lactam antibiotics, those with allergic tendencies, patients with severely impaired kidney function, patients unable to take orally or elderly patients, and those in poor general condition. Possible side effects include headache, dizziness, diarrhea, nausea, and skin rash. Rarely, serious skin reactions, interstitial pneumonia, and renal impairment may occur, and any unusual symptoms should be reported to a physician immediately. To prevent the emergence of antibiotic-resistant bacteria, it is important to confirm the susceptibility of the infecting organism and administer the drug for the necessary duration only. As allergic reactions or shock may occur, detailed medical history and careful monitoring during administration are required. This medication may cause an imbalance of intestinal flora, leading to excessive growth of Candida species or pseudomembranous colitis, so caution is advised with long-term use. Dizziness may occur while driving or operating machinery, so caution is necessary. There may be drug interactions, so caution is advised when taken with diuretics, aminoglycoside antibiotics, probenecid, antacids, etc. Women who are pregnant or breastfeeding should have the use of this drug carefully evaluated, especially in early pregnancy, and should consult a physician. Caution is advised for children, especially infants under 3 months, as safety has not been established. It is recommended to use a granule preparation due to the bitter taste when crushing the tablets for feeding. Elderly patients should be closely monitored for possible bleeding tendencies due to renal impairment and vitamin K deficiency, adjusting the dose and intervals as necessary. This medication may affect certain clinical test results, so inform the healthcare personnel of its use before any tests. Overdosage may lead to neurological symptoms such as seizures, hence strict adherence to prescribed dosages is necessary. If needed, blood dialysis or peritoneal dialysis can be performed to reduce drug concentration. Keep this medicine out of the reach of children, and store it in its original container to prevent misuse or quality degradation.

• Candida overgrowth
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• erythrocytopenia
• hemoglobin decrease
• hematocrit decrease
• hemolytic anemia

Store this medication in a sealed container to protect it from air and moisture. It is advisable to maintain a room temperature between 1 and 30 degrees Celsius.

Appearance

White rectangular film-coated tablets

Package unit

50 tablets (10 tablets/PTP x 5)