Kretrol Tablet 10/5 mg

Adult dose

This medication is taken once daily without regard to meals. The dosage range is 10/5 mg to 10/20 mg daily. The recommended starting dose is 10/5 mg daily. In cases where a more significant reduction in LDL cholesterol is required, the dose can be adjusted. After initiation of therapy or adjustment of dosage, lipid levels should be checked at intervals of at least 4 weeks, and adjustments made accordingly.

This medication has been reported to rarely cause rhabdomyolysis, which can lead to serious kidney problems due to muscle tissue damage. Therefore, patients experiencing severe muscle pain or weakness, or those with risk factors such as severe infections, hypotension, major surgery, trauma, or serious metabolic disorders should temporarily discontinue or stop this medication. Patients allergic to components of this medication, those with active liver diseases, muscle disease patients, patients with severely impaired renal function, pregnant women, or nursing mothers should not take this medication. Moreover, patients with moderate to severe renal impairment, hypothyroidism, a family history of muscle disease, or those who are on specific medications that increase the risk of muscle damage should be particularly cautious when taking this medication. As this medication contains lactose, it should not be administered to patients with genetic issues such as lactose intolerance. Caution is also required in patients with a history of alcoholism or liver disease, moderate liver dysfunction, elderly patients, and those with risk factors for myopathy; special care is advised when combined with fibrate-type medications. If symptoms such as muscle pain, cramps, fatigue, or warmth occur while taking this medication, patients should notify their doctor immediately and be examined; in severe cases, the medication should be discontinued. Liver function abnormalities may appear, thus liver function tests should be conducted before and during treatment, and if liver enzyme levels increase significantly, the medication should be stopped. This medication may slightly raise blood glucose levels; however, the reduction of cardiovascular risks outweighs the potential risk of severe diabetes development, hence does not warrant discontinuation. It must be discontinued during pregnancy as it may be harmful to the fetus, and nursing mothers should avoid this medication as well. This medication is not recommended for children as its safety and efficacy have not been adequately established. Due to the risk of myopathy in the elderly, it should be used with caution. This medication may interact with other drugs, so patients should always inform their doctor or pharmacist of other medications they are taking, particularly with certain antibiotics, antivirals, anticoagulants, and fibrate-type drugs. There is no specific antidote for overdose; treatment is symptomatic, and liver function and muscle damage should be checked. Lastly, this medication should be kept out of reach of children and should not be transferred to another container.

Serious side effects

Hives, edema, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, serious skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, jaundice, a very lethargic body, liver abnormality, sudden and severe headache, lightning headache, fainting

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• myalgia
• swelling
• elevated blood bilirubin
• acneiform dermatitis
• pruritus

This medication should be stored in a tightly closed container to protect it from air and moisture, with a storage temperature maintained between 1 to 30 degrees Celsius in a cool, dry place. Proper storage will help maintain the effectiveness and safety of the medication for a longer duration.

Appearance

White to almost white round film-coated tablet

Package unit

Blister - 30 tablets/blister [10 tablets/blister × 3], Bottle - 30 tablets/bottle, Bottle - 300 tablets/bottle