Topstatin F Tablets 10/20 Milligrams

Adult dose

This medication is administered once daily without regard to meals. The recommended dosage range is 10/5mg to 10/20mg daily, with an initial dose of 10/5mg recommended. For patients requiring a greater reduction in LDL cholesterol, the dose may be adjusted accordingly. After initiation of therapy or dose adjustment, lipid levels should be monitored at intervals of 4 weeks or more, and the dose may be adjusted as necessary, up to a maximum of 10/20mg per day.

This medication can cause a rare side effect called rhabdomyolysis, which can lead to serious muscle problems, so patients must immediately inform their doctor if they experience severe muscle pain or weakness. Patients at risk of worsening kidney function due to severe infections, hypotension, major surgeries or trauma, or severe metabolic disorders may need to temporarily discontinue this medication. It should not be used in patients who are allergic to any ingredient, have active liver disease or persistently elevated liver enzyme levels, have a muscle disorder, have severe kidney function impairment, are pregnant or may become pregnant, or are breastfeeding. Caution should be taken when taken with specific medications such as cyclosporine or fibrate-class drugs, as this may increase the risk of muscle injury. This medication contains lactose and should not be administered to patients with lactose intolerance or related genetic disorders. Alcoholics or those with a history of liver disease, elderly patients, and those with hypothyroidism who are at high risk of myopathy should use this medication cautiously, requiring regular blood testing and symptom observation. This medication may affect liver function, so liver function tests should be performed before and during treatment, and any symptoms of liver damage should be immediately reported to healthcare professionals. Blood glucose levels can increase, so patients at risk of diabetes should manage their blood sugar effectively. Since there might be interactions with other medications during the use of this medication, all medications being taken should be disclosed to healthcare providers, especially when combined with warfarin or certain antibiotics, antifungal, and antiviral medications. Pregnant or breastfeeding women should not take this medication, and fertile women should use appropriate contraception while on it. Safety in children or adolescents has not been sufficiently established, so it is advisable not to use it except in special cases. In case of overdose, there are no specific antidotes, and treatment should be appropriately directed based on symptoms, while monitoring liver function and muscle enzyme levels. This medication should be kept out of the reach of children, and transferring it to other containers should be avoided.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, cold sweats, difficulty breathing, severe allergic reactions, severe rash with fever, blisters, peeling skin, pain in oral/ocular mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory difficulties accompanied by coughing and fever, respiratory issues, jaundice (yellowing of the skin or eyes), extreme lethargy, liver abnormalities (jaundice), sudden and severe

Mild side effects

• Nasopharyngitis
• arthralgia
• headache
• dizziness
• upper respiratory infection
• myalgia
• pruritus
• acneiform dermatitis
• elevated bilirubin levels
• edema

This medication should be stored in a tightly closed container to prevent exposure to air or moisture, preferably at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's efficacy for a longer period.

Appearance

White to nearly white round film-coated tablets

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle, PTP - 30 tablets/box [10 tablets/PTP×3]