Credible Tablets 10/20 mg (Ezetimibe, Rosuvastatin Calcium)

Adult dose

This medication is administered once daily, regardless of meals. The dosage range is 10/5 mg to 10/20 mg per day. An initial dose of 10/5 mg per day is recommended. In patients requiring a greater reduction in LDL-cholesterol, the dosage may be adjusted accordingly. After starting treatment or adjusting the dosage, check blood lipid levels at intervals of more than 4 weeks. The maximum daily dosage can be increased up to 10/20 mg.

This medication can cause a rare serious side effect called rhabdomyolysis, which can lead to severe muscle problems. In particular, if there are risk factors such as severe infections, hypotension, major surgery, trauma, severe metabolic disorders, or uncontrolled seizures, the use of this medication should be temporarily stopped or discontinued. Patients with allergic reactions to the active ingredient or components of this medication should not take it, nor should it be administered to patients with severe liver dysfunction or muscle diseases. Additionally, it is contraindicated in patients with severely impaired renal function, women who are pregnant or may become pregnant, and women who are breastfeeding. Caution should be exercised when administering this medication to patients at high risk of developing myopathy or rhabdomyolysis, such as those with renal impairment, hypothyroidism, a history of genetic muscle disorders, a history of myotoxicity from statins or fibrates, alcoholics, and Asian patients. This medication may cause liver dysfunction, so liver function tests should be conducted before and during treatment, and treatment should be halted if liver enzyme levels significantly increase. If symptoms such as muscle pain, muscle cramps, muscle weakness, fatigue, fever, etc. occur during treatment, the physician should be informed immediately, and in severe cases, the medication should be discontinued. This medication can interact with other drugs, so patients must inform their physician or pharmacist, especially if they are taking anticoagulants, fibrates, certain antibiotics, antifungals, or immunosuppressants. Women who are pregnant or breastfeeding should not take this medication, and women of childbearing age should employ appropriate contraception while on treatment. This medication requires special attention in children and the elderly, and safety in pediatric populations has not been adequately established. In cases of overdose, there is no specific antidote, so appropriate treatment and supportive therapy should be administered based on symptoms, and liver function and muscle enzyme levels should be regularly monitored. This medication should be kept out of reach of children and should not be transferred to other containers.

Serious side effects

• Myopathy
• rhabdomyolysis
• acute renal failure
• angioedema
• urticaria
• rash
• chest tightness
• difficulty breathing
• cold sweats
• pallor

Mild side effects

• Nasopharyngitis
• joint pain
• headache
• ALT elevation
• AST elevation
• muscle pain
• elevated blood bilirubin
• acne-like dermatitis
• pruritus
• dizziness

This medication can be sensitive to air and moisture, so it must be stored in a tightly sealed container. The storage temperature should be maintained between 1 degree and 30 degrees Celsius. This will help maintain the medication's effectiveness for a longer period.

Appearance

White to almost white round film-coated tablet

Package unit

30 tablets (10 tablets/PTP packaging X3), 30 tablets/bottle, 100 tablets/bottle