Simroks EF Tablet

Adult dose

This medication is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10mg to 10/40mg daily, with a generally recommended initial dose of 10/20mg daily. If there is a low necessity to reduce LDL cholesterol, it may be started at 10/10mg daily. After starting the administration or adjusting the dosage, blood lipid levels should be checked at intervals of more than 4 weeks.

This drug may cause muscle-related side effects such as myopathy or rhabdomyolysis, so if you experience muscle pain or weakness while taking it, you should inform your doctor immediately. Patients with allergies to this drug's components or those with impaired liver function, as well as women who are pregnant or breastfeeding, should not take this medication. In particular, those with liver disease or patients with abnormally high liver enzyme levels in blood tests should not be administered this drug, and liver function tests should be performed regularly during treatment. This drug may interact with certain medications, for example, potent CYP3A4 inhibitors, fibrates, some antibiotics, and antifungal agents can increase the risk of myopathy, so you must inform your physician or pharmacist about any medications you are taking. Special caution is required for the elderly, women, patients with hypothyroidism, and those with impaired kidney function, as the risk of muscle side effects is higher in these groups. Women planning to become pregnant should consult their doctor before taking this drug, and should immediately discontinue use if pregnancy is confirmed. Breastfeeding women should stop breastfeeding when taking this drug, and safety and efficacy in children and adolescents have not been fully established, thus caution is needed. If unexplained muscle pain, weakness, or changes in urine color occur while taking this drug, you should promptly consult healthcare professionals. In case of overdose, since there is no specific antidote, appropriate treatment should be received based on symptoms, and when starting or stopping other medications while taking this drug, it must be done according to medical instructions.

Serious side effects

Urticaria, angioedema, hepatitis, pancreatitis, liver failure, skin-mucous membrane syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), erythema multiforme, drug-induced liver injury, myopathy, rhabdomyolysis, severe edema, severe muscle weakness, ocular myasthenia, liver abnormalities (jaundice), severe allergic reactions, serious skin adverse reactions, respiratory issues, severe neurological symptoms, significantly decreased urine output, increased blood pressure

Mild side effects

• Headache
• diarrhea
• influenza
• upper respiratory tract infection
• muscle pain
• limb pain
• fatigue
• abdominal pain
• nausea
• constipation

This medication should be stored in a tightly sealed container to prevent air and moisture from entering. In addition, it is best to store the medication at room temperature between 1°C and 30°C, avoiding areas that are too hot or too cold.

Appearance

A white to off-white, biconvex, rectangular tablet

Package unit

30 tablets ((10 tablets/PTP)x3)