Gripide Tablets (Glimepiride)

Adult dose

Take once daily by mouth. Should be taken before or just prior to the first meal of the day. Start at a dosage of 1 mg of glimepiride once daily, increasing by 1 mg at intervals of 1 to 2 weeks if necessary. Generally, an additional effect is rarely seen with doses over 4 mg, but can be increased to 6 mg (or 8 mg) if needed. If a daily dose of 4 mg fails, consider transitioning to insulin therapy.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or those in a coma. Additionally, it should not be administered to individuals allergic to this medication or sulfonylureas, patients with severe liver or kidney dysfunction, and women who are pregnant or breastfeeding. Patients with severe infections, pre- and post-operative periods, or those with severe trauma are also recommended to use insulin therapy instead. Individuals with gastrointestinal disorders that impair food absorption should be cautious as they may have a risk of hypoglycemia. In the first week of taking this medication, there is a high risk of hypoglycemia, so blood sugar levels should be closely monitored. Particularly, elderly patients, those with poor nutritional status or irregular meal patterns, individuals who have insufficient carbohydrate intake after excessive exercise, and those who consume large amounts of alcohol are more susceptible to hypoglycemia. Individuals with poor kidney or liver function and those taking other medications should also be cautious. Symptoms of hypoglycemia may appear with this medication, including headache, severe hunger, nausea, fatigue, anxiety, confusion, drowsiness, and loss of consciousness. Hypoglycemia usually recovers quickly after sugar intake, so it is advisable to always carry sugary foods. Additionally, gastrointestinal symptoms such as blurred vision, nausea, abdominal pain, diarrhea, abnormal liver function, blood abnormalities, and allergic reactions may occur, so any unusual symptoms should be promptly discussed with medical personnel. It is important to carry out dietary and exercise therapy in conjunction with this medication for blood sugar control, and continuous use is needed to see effects. As hypoglycemia may occur, it is essential to fully understand the symptoms and risk factors and to be cautious while driving or operating machinery. In stressful situations, infections, or surgeries that make blood sugar control difficult, switching to insulin therapy may be considered. It is safest for women who are pregnant or breastfeeding not to use this medication, and if planning to become pregnant, they should consult their doctor. In case of overdose, severe hypoglycemia may occur, so immediate emergency treatment and a visit to a medical facility should be obtained if symptoms arise. Lastly, the safety and efficacy of this medication in children have not been established, and dosages for the elderly should be adjusted based on renal function. This medication should be kept out of the reach of children and stored in its original container to maintain quality.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, drop in blood pressure, shock, angioedema, Stevens-Johnson syndrome (skin and mucosal syndrome), abnormal liver function (jaundice), hepatitis, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility or activity

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is recommended to maintain storage temperatures between 1 and 30 degrees Celsius. Storing this way will help to maintain the efficacy of the medication for a longer period.

Appearance

Green rectangular tablets

Package unit

30 tablets, 100 tablets