Donepin 5mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. For 4 to 6 weeks, provide the 5 mg dosage, and after evaluating the clinical response, it can be increased to 10 mg. If increasing to 10 mg daily, care should be taken regarding gastrointestinal adverse reactions. Underweight female patients aged 85 and older should not exceed 5 mg daily.

Child dose

There is no experience of use in children.

This medication uses Donepezil Hydrochloride as the main ingredient for the treatment of Alzheimer's dementia symptoms. First, this drug should not be used in patients who are allergic to Donepezil Hydrochloride, piperidine derivatives, or any of its components, in women who are pregnant or might become pregnant, and in nursing mothers. Additionally, since it contains lactose, it should not be administered to patients with genetic conditions such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. Patients with heart disease or those with heart conduction disturbances, patients taking non-steroidal anti-inflammatory drugs or have a history of peptic ulcers, patients with asthma or chronic obstructive pulmonary disease, and patients with extrapyramidal disorders such as Parkinson's disease should use this drug with caution. Due to its vagal nerve stimulating effect, this medication may cause cardiac-related side effects such as bradycardia, heart block, and QT interval prolongation, so patients with heart disease need to be particularly careful. In the gastrointestinal tract, increased gastric acid secretion and enhanced gastrointestinal motility may worsen peptic ulcers, so symptoms need to be monitored. Moreover, this medication enhances bronchial smooth muscle contraction and mucus secretion, which may aggravate symptoms of asthma or chronic obstructive pulmonary disease. Patients with extrapyramidal disorders may exhibit motor dysfunctions, tremors, and involuntary movements, thus requiring caution. Reported side effects of this medication include nausea, vomiting, diarrhea, loss of appetite, dizziness, insomnia, hallucinations, bradycardia, palpitations, liver function impairment, rash, and myalgia. Serious side effects, though rare, can include heart attack, cerebral hemorrhage, kidney failure, acute pancreatitis, rhabdomyolysis, and convulsions, and any unusual symptoms should be immediately discussed with a healthcare professional. This medication is primarily metabolized in the liver, thus patients with liver impairment require dosage adjustment and monitoring. Pregnant or nursing women are advised not to use this medication, and if necessary, it should be done under professional guidance. This medication can interact with other drugs, so caution is needed, especially when taken with heart medications, antibiotics, antidepressants, antipsychotics, and anti-inflammatory drugs. Dizziness or fatigue may arise during driving or operating machinery, thus caution should be observed particularly at the beginning of treatment or during dosage adjustments. In case of overdose, symptoms may include nausea, vomiting, sweating, bradycardia, respiratory depression, and convulsions, and immediate emergency treatment is required. This medication should not be used in children as its safety has not been established, and it should be stored out of reach of children.

Serious side effects

Syncope, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcers, perforated duodenal perforation, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, convulsions, cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (motor dysfunction, ataxia, tremors, gait disturbances, involuntary movements, speech disorders), neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute kidney failure, unexplained sudden death

Mild side effects

• Nausea
• vomiting
• diarrhea
• headache
• dizziness
• insomnia
• fever
• loss of appetite
• fatigue
• drowsiness

This medication should be stored in a tightly sealed container to prevent air or moisture from entering, and it is recommended to store it at room temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness and prevents degradation.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle