Esoprazole 20 mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medicine should be swallowed with a liquid such as water. Do not chew or crush it. Adults 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: Administer 40 mg once daily for 4 weeks. Patients whose esophagitis has not healed or whose symptoms persist should take it for an additional 4 weeks. - Long-term maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: · 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical evaluation is needed. · Once symptoms have resolved, subsequent symptoms may be controlled with 20 mg once daily. · In adults, 20 mg may be taken once daily as needed. As-needed use to control recurring symptoms is not recommended for patients at high risk of gastric and duodenal ulcers due to nonsteroidal anti-inflammatory drug use. 2) Combination therapy with antibiotics for Helicobacter pylori eradication Administer this medicine 20 mg with amoxicillin 1 g and clarithromycin 500 mg twice daily for 7 days. 3) Short-term treatment of upper gastrointestinal symptoms (pain, discomfort, burning sensation) associated with the use of nonsteroidal anti-inflammatory drugs (nonselective or selective COX-2 inhibitors) - 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical evaluation is needed. Clinical studies extending beyond 4 weeks have not been conducted. 4) Patients requiring continued treatment with nonsteroidal anti-inflammatory drugs - Treatment of gastric ulcers associated with nonsteroidal anti-inflammatory drug use: 20 mg once daily. The treatment period is 4∼8 weeks. - Prevention of gastric and duodenal ulcers associated with nonsteroidal anti-inflammatory drug use: 20 mg once daily. 5) Treatment of Zollinger-Ellison syndrome The recommended initial dose is 40 mg twice daily. The dose should then be adjusted individually, and treatment should continue while clinical symptoms are present. According to clinical data, most patients can be controlled with doses of 80 ∼ 160 mg per day. Doses greater than 80 mg per day should be divided into two doses. 6) Maintenance therapy following intravenous induction to prevent rebleeding due to gastric or duodenal ulcers After intravenous induction to prevent rebleeding due to gastric or duodenal ulcers, administer 40 mg once daily for 4 weeks. 4. Renal impairment No dose adjustment is necessary. Use with caution because there is limited experience with administration to patients with severe renal impairment. 5. Hepatic impairment No dose adjustment is necessary in patients with mild to moderate hepatic impairment. Patients with severe hepatic impairment should not exceed a dose of 20 mg of this medicine. 6. Elderly patients No dose adjustment is necessary.

Children's dosage

Adolescents 12 years of age and older — Gastroesophageal reflux disease (GERD), treatment of erosive reflux esophagitis: Administer 40 mg once daily for 4 weeks. Patients whose esophagitis has not healed or whose symptoms persist should take the medication for an additional 4 weeks. Adolescents 12 years of age and older — Gastroesophageal reflux disease (GERD), symptomatic treatment of gastroesophageal reflux disease without esophagitis: 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is needed. Adolescents 12 years of age and older — Gastroesophageal reflux disease (GERD), symptomatic treatment of gastroesophageal reflux disease without esophagitis: Once symptoms have resolved, subsequent recurring symptoms are controlled by administering 20 mg once daily. Adolescents 12 years of age and older — Gastroesophageal reflux disease (GERD), symptomatic treatment of gastroesophageal reflux disease without esophagitis: In adults, 20 mg may be taken once daily as needed. As-needed administration is not recommended to control recurring symptoms in patients at high risk of developing gastric and duodenal ulcers due to nonsteroidal anti-inflammatory drug use. Children under 12 years of age — There is no experience with administration of this medication to children under 12 years of age.

This medicine should not be administered to certain patients. For example, patients with an allergy to this medication or its ingredients, those with hypersensitivity to benzimidazole derivatives, and those allergic to penicillins or macrolide antibiotics should not use this medication. Additionally, patients taking certain heart-related medications, with a history of myocardial infarction, or nursing women should avoid using this medication. This medication can cause various side effects, with common symptoms including headache, abdominal pain, diarrhea, and nausea. Rarely, serious side effects can occur, such as blood abnormalities, hypersensitivity reactions, neurological abnormalities, liver function abnormalities, and skin rashes. Therefore, if any abnormal symptoms occur, it is vital to consult with healthcare professionals immediately. Long-term use of this medication requires regular monitoring, and metabolic abnormalities such as increased fracture risk or hypomagnesemia may occur, so caution is necessary. This medication can interact with other drugs, so especially when combined with antibiotics, antiviral medications, or anticoagulants, it is essential to consult with a doctor or pharmacist. The safety of this medication during pregnancy has not been fully established, so pregnant women should be cautious when taking this medication, and nursing women should avoid it. In case of overdose, there is no specific antidote, so it is crucial to receive symptomatic treatment, and caution is required as this medication is not removed by dialysis. Finally, keep this medication out of reach of children, do not change the medicine container, and if any changes in symptoms or adverse reactions occur during the medication, consult with a professional.

Leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, fever, angioedema, anaphylaxis, shock, peripheral edema, hyponatremia, hypomagnesemia, insomnia, anxiety, mental confusion, depression, aggression, hallucinations, headache, dizziness, paresthesia, drowsiness, taste disturbance, blurred vision, bronchospasm, pancreatitis, abdominal pain, constipation, diarrhea, abdominal distension, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, microscopic colitis, increased liver enzymes, jaundice, hepatitis, liver failure, encephalopathy, dermatitis, itching, rash, urticaria, hair loss, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized pustular psoriasis, drug reactions with eosinophilia and systemic symptoms, fractures, arthralgia, myalgia, muscle weakness, interstitial nephritis, gynecomastia, asthenia, increased sweating, Clostridium difficile-associated diarrhea, abdominal bloating, allergic reactions, back pain, chest pain, retrosternal pain, facial edema, facial flushing, fatigue, fever, influenza-like illness, generalized edema, leg edema, malaise, pain, stiffness, peripheral edema, flushing, hypertension, tachycardia, goiter, irritable bowel syndrome, constipation worsening, dyspepsia, dysphagia, gastrointestinal development disorder, epigastric pain, belching, esophageal disorder, frequent bowel movements, gastroenteritis, gastrointestinal bleeding, hiccups, melena, oral disorders, pharyngeal disorders, rectal disorders, gastrointestinal symptoms, increased serum gastrin, tongue disorders, tongue swelling, ulcerative stomatitis, earache, tinnitus, anemia, hypopigmented anemia, cervical lymphadenopathy, epistaxis, leukocytosis, leukopenia, thrombocytopenia, hyperbilirubinemia, liver function abnormalities, elevated ALT, elevated AST, diabetes, hyperuricemia, elevated ALP, polydipsia, vitamin B12 deficiency, weight gain, weight loss, exacerbation of arthritis, arthropathy, seizures, fibromyalgia syndrome, hernia, polymyalgia rheumatica, decreased appetite, apathy, increased appetite, confusion, worsening depression, hypertonia, sensory loss, erectile dysfunction, insomnia, migraine, exacerbation of migraine, sleep disorders, tremors, visual field defects, dysmenorrhea, menstrual disorders, vaginitis, exacerbation of asthma, cough, dyspnea, laryngeal edema, pharyngitis, rhinitis, sinusitis, acne, anal itching, erythematous rash, papular rash, otitis media, abnormal olfaction, loss of taste, taste distortion, urinary abnormalities, albuminuria, cystitis, dysuria, fungal infections, hematuria, urination frequency, candidiasis, genital candidiasis, polyuria, conjunctivitis, visual disturbances, duodenitis, esophagitis, esophageal stricture, esophageal ulcer, esophageal varices, gastric ulcer, gastritis, benign polyps or nodules, Barrett's esophagus, mucosal discoloration, hernia, systemic lupus erythematosus, cutaneous lupus erythematosus, hypocalcemia, hypokalemia, rhabdomyolysis, myalgia, elevated creatine kinase, elevated serum and urinary myoglobin

This medication should be stored in a tightly sealed container to avoid exposure to air and moisture. It is recommended to keep the storage temperature between 1 to 30 degrees Celsius at room temperature.

Appearance

Round film-coated tablet, light pink in color

Package unit

28 tablets (14 tablets x 2 PTP)