Clarithromycin 500 mg Tablet

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The treatment period is usually 7–14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, reduce the dose by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this drug twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this drug 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1–14), and administer omeprazole 40mg once daily for 28 days (days 1–28).

Children's dosage

Children aged 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in certain patients. For example, those allergic to the additives included in this medication or to macrolide antibiotics should avoid administration. Furthermore, it may pose risks if administered with drugs that can affect heart rhythm, thus caution is needed for patients with specific heart conditions or those taking heart-related medications. The use of this medication may not be suitable for patients with severely impaired liver or kidney function, and dosage adjustments may be necessary. It is safest for pregnant or breastfeeding women not to take this medication. While taking this medication, allergic reactions, gastrointestinal issues, skin rash, and neurological symptoms may occur, so immediate consultation with healthcare providers is required if symptoms arise. This medication interacts with many other drugs, which may increase side effects or alter effectiveness, so it is crucial to inform the healthcare provider about any other medications being taken. In particular, caution is advised when used with blood glucose-lowering medications, heart-related drugs, certain antibiotics, antifungals, etc. Elderly patients or those with impaired liver or kidney function may have elevated blood concentrations of this medication, so careful administration is necessary. Long-term or repeated use of this medication can lead to resistant bacteria, so it is important to take it only for the prescribed duration as directed by a physician. If diarrhea, abdominal pain, or fever occurs, it may indicate serious gastrointestinal conditions such as pseudomembranous colitis, requiring immediate medical attention. This medication can cause dizziness or confusion when driving or operating machinery, so caution is needed. Overdose may lead to gastrointestinal disturbances or psychiatric symptoms, so dosage must be adhered to, and immediate emergency treatment is required in case of overdose. This medication requires proper storage, especially dry syrups should be kept at room temperature and not refrigerated.

Shock, anaphylactic symptoms, shortness of breath, convulsions, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, color changes in stool, membranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltrates, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, derealization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular or cholestatic hepatitis, increased liver enzyme levels, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, elevated total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste disorders, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbances, hypoglycemia, tinnitus, auditory impairment, purpuric rash, acute generalized exanthematous pustulosis, muscle cramps, musculoskeletal rigidity, myopathy, elevated blood creatinine, increased blood urea, renal failure, nephritis, phlebitis at the injection site, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine color changes

This medication is sensitive to light, so it should be stored in a tightly sealed container that blocks light. Additionally, it is best to store the medication at room temperature between 15 and 30 degrees Celsius to maintain its efficacy over time.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle