Donepezil 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Administer 5 mg once daily before bedtime as donepezil hydrochloride. For 4 to 6 weeks, continue to administer 5 mg, after which clinical response should be evaluated to potentially increase to 10 mg. When increasing to 10 mg per day, monitor for gastrointestinal adverse reactions. Underweight elderly women should not exceed 5 mg per day.

Child dose

No experience with use in children.

This medication contains donepezil hydrochloride and is primarily used to treat the symptoms of Alzheimer's disease. This medication should not be used in certain patients. For example, it should not be administered to individuals with allergies to this medication or its components, as well as pregnant or breastfeeding women, and patients with genetic issues such as lactose intolerance. Patients with heart conditions, asthma, chronic obstructive pulmonary disease, or a history of peptic ulcers should be particularly cautious when using this medication, as it may affect heart rhythm and exacerbate gastrointestinal symptoms. Various adverse reactions may occur when using this medication. For instance, cardiovascular problems, gastrointestinal bleeding, liver dysfunction, neurological symptoms, motor function disorders, and serious neurological anomalies have been reported. Therefore, if symptoms are severe or abnormal signs appear, immediate consultation with healthcare professionals is necessary. Additionally, this medication is not approved for memory disorders that are not related to dementia and should be used only under the diagnosis and supervision of a specialist. The therapeutic effect should be regularly evaluated, and if there is no effect, discontinuation should be considered. This medication is primarily metabolized in the liver, thus patients with impaired liver function may require dose adjustments. Furthermore, this medication can interact with other drugs, so it is essential to inform healthcare professionals about any medications being taken. Pregnant or breastfeeding women should not use this medication, and use should only occur after consulting a specialist if absolutely necessary. Safety in children has not been established, and therefore, it should not be administered to children. In case of overdose, serious symptoms such as nausea, vomiting, bradycardia, hypotension, and seizures may occur, requiring immediate treatment, which may include antidotes such as atropine. This medication should be stored out of reach of children, and transferring it to other containers should be avoided as it may affect quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe allergic reactions, severe rashes with fever, blisters, skin peeling, pain in oral/eye mucosa, serious skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, cough with fever associated respiratory problems, jaundice (yellowing of the skin or eyes), extreme lethargy, liver abnormalities (jaundice).

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• hallucinations
• agitation

This medication should be stored in a tightly sealed container to prevent air exposure and is best kept at room temperature between 1 degree and 30 degrees Celsius. This helps maintain the efficacy of the medication and prevents degradation.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle