Hepsevir Tablet 10 mg (Adefovir Dipivoxil)

Adult dose

Adults: Administer 10 mg of adefovir dipivoxil orally once daily, with or without food. Patients with renal impairment: In patients with a creatinine clearance of less than 50 mL/min, the dosing interval should be adjusted as shown in the table below. The pharmacokinetics of adefovir have not been evaluated in patients with a creatinine clearance of less than 10 mL/min who are not receiving hemodialysis; therefore, no dosing recommendations are available for these patients.

This medication must be taken exactly as prescribed and should not exceed the recommended dosage. Abrupt discontinuation of treatment may lead to a serious exacerbation of hepatitis B; therefore, regular liver function tests should be performed for a certain period after discontinuation. Patients with severely impaired liver function or cirrhosis should monitor their liver status more closely at the beginning of treatment. This medication may affect kidney function; therefore, patients with renal disease or those at risk should undergo kidney function testing before use and continue to monitor renal function during treatment. Safety for patients with end-stage renal disease undergoing hemodialysis has not been fully confirmed. This medication should only be used after confirming HIV infection status, and patients infected with HIV should first receive appropriate antiviral treatment. Pregnant women should use this drug carefully, as the effects on the fetus are not fully known, and it should only be used when absolutely necessary. Breastfeeding women are advised to avoid breastfeeding while taking this medication. The safety for children and adolescents has not been fully established. Elderly patients may have reduced kidney and heart function, so caution is required during use. In case of overdose, immediately inform a healthcare professional, and if necessary, the drug can be removed through hemodialysis. This medication may interact with other drugs that affect kidney function; therefore, you must consult with your healthcare provider regarding concomitant medications. The effects on driving or operating machinery are not known, but no specific effects are anticipated. During treatment with this medication, liver function, kidney function, and blood test results should be monitored regularly, and any abnormal symptoms should be reported to a healthcare professional immediately.

• Worsening hepatitis
• elevated serum ALT
• increased serum creatinine
• decreased serum phosphorus
• weakness
• headache
• fever
• abdominal pain
• nausea
• vomiting

This medication may be sensitive to air and moisture, so it must be stored in a tightly closed container. It is recommended to maintain a storage temperature between 1°C and 30°C at room temperature. This will help preserve the drug's effectiveness for a longer period.

Appearance

White to grayish white round tablet

Package unit

30 tablets/bottle