Clothens Tablets (Clopidogrel Sulfate)

Adult dosage

1. For patients with ischemic stroke, myocardial infarction, or peripheral artery disease, administer 75 mg of clopidogrel once daily orally. 2. For patients with acute coronary syndrome (unstable angina or non-ST elevation myocardial infarction), start with a loading dose of 300 mg once daily on the first day, followed by a maintenance dose of 75 mg once daily orally. At this time, aspirin 75–325 mg should be co-administered once daily.

This drug prevents the aggregation of platelets in the blood to prevent the formation of clots. It must be converted into its active form by a specific enzyme in the liver, CYP2C19, to be effective. Individuals who genetically have reduced function of this enzyme may experience diminished efficacy, so it is advisable to consult a physician. Taking this medication with drugs that activate the CYP2C19 enzyme can increase the concentration of the active metabolite and may elevate the risk of bleeding, so co-administration should be avoided. Patients with allergies to this medication, those with bleeding, individuals with severe liver disease, breastfeeding women, and those with lactose intolerance should not take this drug. Patients at risk of bleeding or with abnormalities in blood coagulation, those scheduled for surgery, elderly patients, and underweight individuals should use this medication cautiously, and report any signs of bleeding to a physician immediately. Since this drug can cause bleeding, it is crucial to undergo tests if symptoms of bleeding occur or if abnormalities are found in blood tests. Additionally, caution is necessary when combined with other medications that carry a bleeding risk. During the course of treatment, bleeding may take longer to stop, so it is crucial to inform medical personnel before any surgery or dental treatment. Rarely, thrombocytopenia or severe blood adverse reactions may occur, thus patients with fever or symptoms of infection should visit a hospital promptly. Side effects may include gastrointestinal disorders, diarrhea, rash, headache, dizziness, and abdominal pain. If pregnant, the effects of this medication on the fetus are minimal; however, due to the risk of bleeding during delivery, consultation with medical personnel is necessary. During breastfeeding, this medication may pass into breast milk, and it is essential to consult with a doctor regarding continuation or discontinuation of breastfeeding. This drug may increase the risk of bleeding in the event of an overdose, and since there is no antidote, treatments such as platelet transfusions may be necessary in cases of severe bleeding. Keep this medication out of reach of children and do not transfer it to other containers for safety. While taking this medication, it is important to routinely visit a physician to reduce the risk of bleeding and always consult with medical personnel regarding interactions with other medications being taken.

Serious side effects

Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attack, abnormal breathing accompanied by coughing or fever, jaundice (yellowing of skin or eyes), profound lethargy, sudden and severe headache, lightning-like headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Chest pain
• accidental injury
• influenza-like illness
• pain
• fatigue
• swelling
• hypertension
• headache
• dizziness
• abdominal pain

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. The recommended storage temperature is room temperature between 1 and 30 degrees Celsius. This helps to maintain the drug's effectiveness over a longer period.

Appearance

Pink, round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle