Evotaz Tablet (Atazanavir Sulfate, Cobicistat, Silicon Dioxide)

Adult dose

In treatment-naive and treatment-experienced adults, the recommended dose of this medicine is 1 tablet once daily, taken with food. This medicine should be administered with other antiretroviral agents. When coadministered with an H2-receptor antagonist or proton pump inhibitor, the dosing times of the medicines may need to be separated. Proton pump inhibitors should not be used in patients who are treatment-experienced and taking this medicine. This medicine is not recommended during pregnancy. Pregnant patients should not initiate treatment with this medicine, and patients who become pregnant while taking it should switch to an alternative therapy.

This medication may cause life-threatening serious drug interactions when used with other medications, so it is essential to consult a doctor or pharmacist to confirm contraindicated drugs. This medication may affect cardiac conduction, leading to atrioventricular conduction abnormalities in electrocardiograms, thus patients with existing cardiac conduction disorders should undergo periodic electrocardiograms. During the use of this medication, blood sugar may increase, or new-onset diabetes may occur, so patients with diabetes should closely monitor their blood sugar levels. Patients who have previously had an allergic reaction to this medication's components or have specific enzyme metabolism issues should not take this medication. This medication is not recommended for patients with impaired kidney function, especially those with decreased creatinine clearance, and regular kidney function tests should be performed. Patients with compromised liver function should also refrain from using this medication. During treatment, symptoms such as skin rash, severe itching, jaundice, and kidney stone symptoms may occur, so any abnormal symptoms should be reported to healthcare professionals immediately. Administration of this medication is not recommended during pregnancy, and if pregnancy occurs while taking this medication, alternative treatments should be initiated. Nursing mothers should avoid taking this medication, as it may transfer to the baby through breast milk. This medication is not recommended for children, especially infants under 3 months of age. Elderly patients should be monitored carefully considering the potential decline in liver, kidney, and heart functions. In case of overdose, there is no specific antidote; therefore, immediate medical attention for vital signs and electrocardiogram monitoring is necessary. Always take this medication with food, and if a dose is missed within 12 hours, take it immediately. If more than 12 hours have passed, take it at the next scheduled time without doubling the dose. Furthermore, this medication can interact with various drugs; hence it is important to inform healthcare providers of all medications being taken and to undergo regular check-ups.

• Cardiac conduction abnormalities
• rash
• elevated serum creatinine
• new or worsening renal impairment
• kidney stones
• cholelithiasis
• hepatotoxicity
• hyperbilirubinemia
• jaundice
• scleral jaundice

This medication should be stored in a tightly sealed container, protected from air and moisture. It is important to maintain room temperature between 1 and 30 degrees Celsius.

Appearance

Pink, oval, bilaterally convex film-coated tablets

Package unit

30 tablets/bottle