Pexostab 80 mg (Febuxostat)

Adult dosage

40mg or 80mg once daily Administer 40mg or 80mg once daily, with or without food. Recheck the serum uric acid concentration after 2 weeks. The treatment goal is to lower and maintain the serum uric acid concentration below 6 mg/dL(357 μmol/L). No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). No specific dose adjustment is necessary in patients with mild or moderate hepatic impairment. Limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This drug may increase the risk of cardiovascular death when administered to patients with cardiovascular diseases, so those with a history of cardiovascular disease should consider alternative treatment methods first. Patients with allergies to this drug's active ingredient or excipients, those taking certain medications (mercaptopurine, azathioprine), and those with genetic issues such as lactose intolerance should not use this drug. Patients with liver disease or changes in thyroid function should undergo regular liver function tests and thyroid function tests while taking this drug, and caution is also necessary for patients with heart disease or those taking certain medications (theophylline). This drug can cause various side effects such as liver dysfunction, diarrhea, headache, rash, fatigue, and dizziness, so immediate consultation with healthcare professionals is necessary if abnormal symptoms occur. This medication should not be started during an acute gout attack, and it is recommended to co-administer other medications to prevent exacerbation of gout during the initial administration as gout attacks may temporarily worsen. This drug may impact liver function, so liver function tests must be conducted before and during treatment, and administration must be stopped immediately if symptoms indicating liver dysfunction appear. This drug may interact with certain medications, so you must inform your healthcare provider of any other medications you are taking, especially when co-administering mercaptopurine, azathioprine, or theophylline. Pregnant or nursing women should preferably not take this drug, and there is no experience in using it in children under 18 years of age, so it should not be administered to them. No special dosage adjustment is needed for the elderly, but attention should be paid to responses from the body. There are no specific reports of overdose, but appropriate treatment should be sought based on symptoms, and it should be stored safely out of reach of children.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, muscle pain, pruritus, dyspnea, anemia, thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina pectoris, atrial fibrillation, atrial flutter, heart murmur, abnormal electrocardiogram, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel movements, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, melena, oral ulcer, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, mood changes, gait disturbance, influenza-like symptoms, mass, pain, thirst, cholelithiasis, hyperglycemia, fatty liver, hepatitis, hepatomegaly, hypersensitivity, shingles, loss of appetite, reduced appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint edema, muscle cramps, muscle fasciculation, muscle spasms, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disorders, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, decreased sense of smell, heat stroke, drowsiness, mental disorders, migraine, sensory disturbances, somnolence, transient ischemic attack, tremors, agitation, anxiety, depression, insomnia, excitability, decreased libido, irritability, panic attacks, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, coughing, dyspnea, epistaxis, nasal dryness, excessive sinus secretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin pigmentation disorders, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin desquamation, petechial hemorrhage, photosensitivity, pruritus, purpura, skin discoloration, pigmentation changes, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, prolonged activated partial thromboplastin time, elevated creatinine, decreased bicarbonate, elevated sodium, abnormal EEG, elevated glucose, elevated cholesterol, elevated triglycerides, elevated amylase, elevated potassium, elevated thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, elevated creatinine, increased blood urea nitrogen, increased blood urea nitrogen to creatinine ratio, elevated CPK, elevated ALP, elevated LDH, elevated PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased white blood cell count, decreased white blood cell count, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive urine leukocytes, positive urine protein, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, drug reaction accompanied by eosinophilia and systemic symptoms, liver failure, jaundice, liver impairment, agranulocytosis, rhabdomyolysis

This drug should be stored in a tightly closed container to protect it from air and moisture, ideally at a temperature between 1 degree and 30 degrees Celsius. Proper storage helps maintain the drug's effectiveness.

Appearance

Light yellow to yellow oblong film-coated tablet with a scored line on one side

Package unit

30 tablets/bottle, 300 tablets/bottle