Crevix Tablets (Clopidogrel Bisulfate)

Adult dosage

For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, clopidogrel should be administered orally at a dose of 75mg once daily. For patients with acute coronary syndrome (unstable angina or non-Q myocardial infarction), therapy should initiate with a loading dose of 300mg orally once daily on the first day, followed by a maintenance dose of 75mg orally once daily thereafter. In this case, aspirin 75-325mg should be co-administered once daily.

This drug is used to prevent the aggregation of platelets in the blood, thus preventing the formation of clots. The efficacy of this drug may be reduced in individuals with genetically diminished function of a specific enzyme (CYP2C19); therefore, treatment modification should be discussed with a physician in such cases. Moreover, taking this drug with other medications that activate this specific enzyme can increase drug concentration and raise bleeding risk, so it is advisable not to use them together. Individuals allergic to this drug or its components, those with active bleeding, severe liver impairment, nursing mothers, and those with specific genetic diseases related to lactose should not take this medication. Patients at risk of bleeding or with suspected bleeding symptoms should undergo blood tests immediately, and caution is needed when taken with anticoagulants like warfarin, as this can further increase the risk of bleeding. This drug should be administered cautiously to individuals with lesions that could cause bleeding in the gastrointestinal tract or eye, those scheduled for trauma or surgery, and individuals with coagulation issues. Particularly if surgery is planned, this medication should be discontinued 5-7 days prior, and it should only be resumed after hemostasis post-surgery. Caution is necessary when taking this drug with other antiplatelet agents, non-steroidal anti-inflammatory drugs (NSAIDs), heparin, selective serotonin reuptake inhibitors (SSRIs), and other medications that may increase bleeding risk. During treatment, careful observation for bleeding symptoms is essential, especially during the initial administration and after cardiac procedures or surgeries where risk of bleeding may arise. Rarely, this drug can cause blood disorders such as thrombocytopenia, agranulocytosis, and aplastic anemia, so any signs of infection or unusual symptoms should be immediately reported to medical personnel. Side effects may include abdominal pain, dyspepsia, diarrhea, rash, headache, and dizziness. In severe cases, medication should be discontinued and medical consultation sought. During pregnancy, this drug is known to have minimal effects on the fetus; however, due to the risk of bleeding during delivery, it is advisable to discontinue use before childbirth. If breastfeeding, there is a possibility of excretion in breast milk, so discussing with a physician whether to stop nursing or adjust medication is important. The safety and efficacy in pediatric patients are not established; hence, this drug should be used cautiously in children. Elderly individuals may have reduced physiological functions, increasing bleeding risk, thus requiring dosage adjustments and monitoring. Patients with severely impaired renal function should also use this drug cautiously, and experience is limited with use in patients with severe liver impairment. In case of overdose, the risk of bleeding increases, and immediate medical attention is required; while there is no antidote for this drug, platelet transfusion can be considered to control bleeding if necessary. This drug should be stored out of reach of children and should not be transferred to other containers.

Serious side effects

• Urticaria
• severe swelling (edema)
• hemorrhagic stroke
• intracranial hemorrhage
• bleeding
• hemorrhagic gastritis
• gastric ulcer
• perforated gastric ulcer
• upper gastrointestinal bleeding
• angioedema

Mild side effects

• Chest pain
• accidental injury
• influenza-like illness
• pain
• fatigue
• edema
• hypertension
• headache
• dizziness
• abdominal pain

This medication should be stored in a tightly closed container to protect it from air and moisture, and it is important to maintain a storage temperature between 1°C and 30°C room temperature to preserve its efficacy.

Appearance

Pink, round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle