Urigat Tablet 40 mg (Febuxostat)

Adult dosage

1. Adults Administer 40mg or 80mg of this medicine once daily, with or without food. Because this medicine acts very rapidly, recheck serum uric acid levels after 2 weeks. The treatment goal is to lower and maintain serum uric acid levels below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dosage adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). 3. Patients with hepatic impairment No special dosage adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This medication may increase cardiovascular mortality in patients with cardiovascular disease; therefore, the risks and benefits should be carefully considered when using it. Patients with allergies to this drug's active ingredient or excipients, those taking mercaptopurine or azathioprine, and those with certain genetic lactose-related conditions should not take this drug. Patients with a history of liver disease or thyroid dysfunction should have regular liver function tests and thyroid function tests while taking this drug, and caution is needed in patients with heart disease or heart failure. This drug may cause various side effects, such as abnormal liver function, diarrhea, headache, rash, dizziness, limb pain, gout, muscle pain, itching, difficulty breathing, anemia, idiopathic thrombocytopenic purpura, leucocytosis/leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation/atrial flutter, heart murmurs, ECG abnormalities, palpitations, bradycardia, tachycardia, hearing impairment, tinnitus, dizziness, blurred vision, abdominal distension; consult medical personnel if any adverse symptoms occur. When an acute gout attack occurs, do not start this medication, and since gout attacks may worsen during the initial period of treatment, it is advisable to use preventive agents such as non-steroidal anti-inflammatory drugs or colchicine for at least 6 months. This medication may cause symptoms such as drowsiness, dizziness, or sensory loss, so driving or operating dangerous machinery should be avoided. This medication is not recommended for use in pregnant or breastfeeding women and has not been tested in children under 18 years of age. If symptoms of liver function decline (fatigue, loss of appetite, jaundice, etc.) occur, discontinue use immediately and get tested; if liver function test results are severely abnormal, this medication should not be resumed. This drug may interact with other specific medications, so caution or avoidance is necessary, especially for those taking mercaptopurine, azathioprine, or theophylline. Regular monitoring of liver function tests and cardiovascular status is important while taking this medication.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, arthralgia, limb pain, gout, myalgia, pruritus, dyspnea, vomiting, arthralgia, rash, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, cardiac murmur, electrocardiogram abnormalities, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel movements, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperacidity, passage of bloody stools, oral ulcers, pancreatitis, gastric ulcer, vomiting, weakness, chest pain, chest discomfort, edema, emotional disturbances, gait disturbances, flu-like symptoms, mass, pain, thirst, cholelithiasis, diabetes mellitus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint edema, muscle spasms, muscle cramping, muscle tightening, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disturbances, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, olfactory loss, heat stroke, drowsiness, mental disorders, migraine, sensory disturbances, drowsiness, transient ischemic attacks, tremor, agitation, anxiety, depression, insomnia, excitability, decreased libido, nervousness, panic attacks, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, excessive nasal secretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory tract infections, alopecia, vascular edema, dermatitis, skin necrosis, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechiae, photosensitivity, pruritus, purpura, skin discoloration, changes in skin pigmentation, skin lesions, apocrine dysfunction, urticaria, flushing, facial flushing, hypertension, hypotension, prolonged activated partial thromboplastin time, increased creatinine, decreased bicarbonate, increased sodium, EEG abnormalities, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea nitrogen, increased blood urea nitrogen to creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased white blood cell count, decreased white blood cell count, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urine casts, positive urinary leukocytes, positive urinary protein, contusions, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, drug reaction with eosinophilia and systemic symptoms, liver failure, jaundice, liver dysfunction, liver dysfunction, agranulocytosis, rhabdomyolysis

Store this medication in a tightly closed container to protect it from air and moisture, and it is safe to store between 1 to 30 degrees Celsius in a cool room.

Appearance

White to yellowish round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle