Neomazole 40 mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medication should be swallowed with liquid such as water and should not be chewed or crushed. 1. Gastroesophageal reflux disease (GERD): - Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. If symptoms persist, an additional 4 weeks should be taken. - Maintenance therapy to prevent recurrence of esophagitis: 20 mg once daily. - Symptomatic treatment for gastroesophageal reflux disease without esophagitis: 20 mg once daily.

Children's dosage

For adolescents aged 12 and older: - Treatment for gastroesophageal reflux disease (GERD) erosive reflux esophagitis: 40 mg once daily for 4 weeks. If symptoms persist, an additional 4 weeks should be taken. - Symptom treatment for gastroesophageal reflux disease without esophagitis: 20 mg once daily.

This medication should not be administered to certain patients. Patients with hypersensitivity to this drug or its components, or to benzimidazole derivatives, should not use it. In addition, when used in combination with amoxicillin or clarithromycin for the eradication of Helicobacter pylori, it should not be given to patients who have hypersensitivity to penicillin antibiotics or macrolide antibiotics. Patients who are taking specific heart-related medications, or those taking atazanavir and nelfinavir, nursing mothers, and patients with a history of myocardial infarction should not use this medication. This medication may cause various adverse reactions. Gastrointestinal symptoms such as headache, abdominal pain, diarrhea, nausea, and vomiting are frequently reported, with rare occurrences of blood abnormalities, skin rashes, liver function abnormalities, and neurological symptoms. Very rarely, serious adverse effects such as severe skin reactions or rhabdomyolysis may occur, so medical advice should be sought immediately if symptoms occur. Regular monitoring is important during long-term use. Particularly, with prolonged use exceeding one year, blood magnesium levels may be decreased, necessitating periodic monitoring. Additionally, as this medication inhibits gastric acid secretion, it may increase the risk of bacterial overgrowth in the gastrointestinal tract; therefore, if symptoms such as diarrhea persist, notify medical personnel. This medication may interact with other drugs. Changes in blood concentration can affect the efficacy of other medications, especially when used in conjunction with warfarin, phenytoin, diazepam, methotrexate, atazanavir, etc., so caution is required. Additionally, when used with certain antibiotics, it may affect the heart, so it must be used strictly according to a doctor's instructions. The safety of this medication during pregnancy has not been fully established, so it should be used with caution; it is advisable not to take this medication while nursing. In cases of overdose, there is no specific antidote, so appropriate treatment should be administered according to symptoms. This medication is not removed by dialysis, so care should be taken. Finally, this medication should be stored out of reach of children, and transferring it to other containers is not recommended as it may negatively affect quality.

Serious side effects

Severe allergic reactions such as urticaria, angioedema, anaphylactic reactions/shock, severe skin reactions such as angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), acute generalized exanthematous pustulosis, eosinophilia, and drug reaction with systemic symptoms (DRESS syndrome), respiratory problems such as bronchospasm, shortness of breath, asthma attacks, hepatitis, hepatic failure, and jaundice.

Mild side effects

• Frequent headaches
• occasional dizziness
• paresthesia
• drowsiness
• agitation
• confusion
• depression
• insomnia
• hallucinations
• abdominal pain

This medication must be stored in a tightly sealed container to protect it from air or moisture exposure. It is important to maintain storage temperatures between 1° and 30°C to ensure the drug's effectiveness.

Appearance

Pink round film-coated tablet

Package unit

PTP - 28 tablets/box [14 tablets/Alu-Alu X 2]