Fesorin 80mg (Febuxostat)

Adult dosage

1. Adults Administer 40mg or 80mg of this medicine once daily, with or without food. Because this medicine acts very rapidly, recheck serum uric acid levels after 2 weeks. The treatment goal is to lower and maintain serum uric acid levels below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dosage adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). 3. Patients with hepatic impairment No special dosage adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This medication may increase the risk of cardiovascular mortality in patients with cardiovascular disease, so patients with a history of cardiovascular disease should consult a doctor before use. Patients with allergies to this medication's active ingredient or excipients, those taking certain immunosuppressants (mercaptopurine, azathioprine), and those with lactose intolerance or specific genetic metabolic disorders should not use this medication. Patients with liver disease or a history of liver issues should regularly monitor liver function and use this medication cautiously. Patients with thyroid dysfunction should also receive thyroid function tests while taking this medication, and caution is needed for patients with heart disease or heart failure. When used in combination with theophylline, the elimination of metabolites may be increased, so caution is advised when taking these two medications together. Do not initiate this medication during an acute gout attack; it should be started after the gout attack is resolved, and preventive treatment may be necessary as gout attacks may temporarily worsen at the beginning of treatment. If symptoms of abnormal liver function (fatigue, loss of appetite, upper abdominal pain, jaundice, etc.) occur, discontinue use immediately and seek medical attention. Dizziness or drowsiness may occur while taking this medication, so caution is necessary when driving or operating dangerous machinery. Pregnant or breastfeeding women are advised not to take this medication, and it should not be administered to children or adolescents under 18 due to a lack of experience with use in this population. This medication may interact with other drugs, so if you are currently taking any medications, be sure to inform your healthcare provider. There is no specific antidote for overdose, so treatment will be symptomatic based on the symptoms. Keep out of reach of children, and no special storage conditions are required.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, arthralgia, limb pain, gout, myalgia, pruritus, dyspnea, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, abnormal electrocardiogram, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel movements, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, excessive hydrochloric acid, passage of blood in stools, oral ulcers, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, mood disturbance, walking difficulties, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes mellitus, fatty liver disease, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle spasm, single muscle contraction, muscle tightness, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disorders, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, reduced sense of smell, heat supratentorial ischemia, drowsiness, mental disorders, migraine, sensory disturbances, somnolence, transient ischemic attack, tremor, restlessness, anxiety, depression, insomnia, excitability, decreased libido, irritability, panic attacks, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, decreased renal function, urinary urgency, urinary incontinence, mastalgia, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, excessive sinus secretion, pharyngeal edema, pulmonary congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin urticaria, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, purpura, photosensitivity, itching, purpura, skin discoloration, pigmentary changes, skin lesions, axillary osmidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, activated partial thromboplastin time prolongation, increased creatinine, decreased bicarbonate, increased sodium, abnormal EEG, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormones, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased erythrocytes, increased creatinine, increased blood urea, increased blood urea nitrogen to creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased white blood cell count, decreased white blood cell count, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urine casts, positive urinary leukocytes, positive urinary protein, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, hepatic failure, jaundice, liver dysfunction, angioedema, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly closed container to prevent air or moisture from entering. It is best to maintain the storage temperature between 1 and 30 degrees Celsius.

Appearance

Pale yellow to yellow oval film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle