Pesorin Tablets 40 mg (Febuxostat)

Adult dosage

1. Adults Administer 40mg or 80mg once daily, with or without food. Because this medicine acts very rapidly, recheck serum uric acid levels after 2 weeks. The treatment goal is to lower and maintain serum uric acid levels below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dosage adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). 3. Patients with hepatic impairment No special dosage adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This medication may increase cardiovascular mortality when administered to patients with cardiovascular disease, so patients with a history of cardiovascular diseases should consider other treatment options. Patients allergic to this drug's active ingredient or excipients, those taking certain medications (mercaptopurine, azathioprine), and patients with genetic issues like lactose intolerance or glucose-galactose malabsorption should not use this drug. Use with caution in patients with a history of liver disease, changes in thyroid function, ischemic heart disease or heart failure, those taking theophylline, organ transplant recipients, patients with significant cardiovascular disease history, and those with very high uric acid production. This medication can cause various side effects including liver function abnormalities, diarrhea, headache, rash, fatigue, muscle pain, dizziness, etc., so consult a doctor immediately if these symptoms occur. Do not start this medication during an acute gout attack; instead, it should be administered after the attack has subsided. Increased gout attacks may temporarily occur at the start of treatment, so preventive medication is recommended. Regular liver function tests are necessary while on this medication, and it should be discontinued immediately if symptoms of liver dysfunction appear. Additionally, this drug may cause drowsiness, dizziness, and numbness, so caution is advised when driving or operating dangerous machinery. Pregnant or breastfeeding women are advised not to take this medication, and it should not be administered to children and adolescents under 18 years old due to a lack of experience in this age group. Be cautious of drug interactions, particularly avoiding concurrent use with mercaptopurine or azathioprine due to potential risks. In the case of overdose, there is no specific antidote; treatment should be symptomatic. This medication should be kept out of the reach of children, and no special storage conditions are required.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, myalgia, pruritus, shortness of breath, vomiting, joint pain, rash, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina pectoris, atrial fibrillation, atrial flutter, cardiac murmur, abnormal electrocardiogram, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, dizziness, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel movements, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, passage of blood in stool, oral ulcer, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, emotional disturbances, walking difficulties, influenza-like symptoms, pain, thirst, cholelithiasis, diabetes mellitus, hepatic steatosis, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, reduced appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramping, muscle single contraction, muscle tightness, muscle weakness, musculoskeletal pain, muscle rigidity, altered taste, balance disorders, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, reduced sense of smell, heat stroke, drowsiness, mental disorders, migraine, sensory abnormalities, sleepiness, transient ischemic attack, tremor, agitation, anxiety, depression, insomnia, excitability, decreased libido, neurosensitivity, panic attack, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, renal insufficiency, urgency, urinary incontinence, mastalgia, erectile dysfunction, gynecomastia, bronchitis, cough, shortness of breath, nosebleed, nasal dryness, excessive sinus secretion, pharyngeal edema, tracheobronchial congestion, sneezing, throat irritation, upper respiratory tract infection, alopecia, vascular edema, dermatitis, skin urticaria, petechial hemorrhage, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin exfoliation, petechiae, photosensitivity, pruritus, purpura, skin discoloration, pigmentation changes, skin lesions, atypical sweating, urticaria, flushing, facial flushing, hypertension, hypotension, activated partial thromboplastin time prolongation, creatinine elevation, bicarbonate reduction, sodium elevation, abnormal EEG, glucose elevation, cholesterol elevation, triglyceride elevation, amylase elevation, potassium elevation, thyroid-stimulating hormone elevation, thrombocyte reduction, hematocrit reduction, hemoglobin reduction, MCV elevation, erythrocyte reduction, creatinine elevation, blood urea elevation, increased blood urea to creatinine ratio, CPK elevation, ALP elevation, LDH elevation, PSA elevation, increased urine output, decreased urine output, lymphocyte count reduction, neutrophil count reduction, leukocyte count increase, leukocyte count decrease, abnormal coagulation tests, low-density lipoprotein elevation, prothrombin time prolongation, urinary casts, positive urine leukocytes, positive urine protein, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, severe allergic reaction, hypersensitivity reaction, eosinophilia, systemic symptoms accompanying drug reactions, hepatic failure, jaundice, liver dysfunction, agranulocytosis, rhabdomyolysis

Store this medication in a sealed container to protect it from air and moisture. It is important to maintain the storage temperature between 1 to 30 degrees Celsius.

Appearance

White to light yellow round film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle