Dihashita Tablet 50/850 mg

Adult dosage

This medicine is generally taken twice daily with food, gradually increasing the dosage to reduce gastrointestinal side effects caused by metformin. 1. Patients who are not currently being treated with metformin: This medication 50/500 mg is taken 1 tablet twice a day, and it can be increased to 50/1000 mg taken 1 tablet twice a day. 2. Patients receiving treatment with metformin:

This medicine is used for the treatment of diabetes and contains two active ingredients: sitagliptin and metformin. First, sitagliptin can rarely cause serious allergic reactions, so if symptoms such as rash, difficulty breathing, or swelling of the face or lips occur, use should be stopped immediately. It can also cause acute pancreatitis, so if symptoms like abdominal pain, nausea, or vomiting arise, consult a doctor promptly. Metformin can cause rare but life-threatening metabolic disorders called lactic acidosis, so it should not be used in patients with poor kidney function or liver dysfunction. This medicine should not be administered to patients with reduced kidney function, severe infections, heart failure, or acute myocardial infarction, and especially should be temporarily discontinued before and after tests using iodinated contrast media. While taking this medication, there is a risk of hypoglycemia, so it is essential to maintain regular meal times and avoid sudden exercise or alcohol consumption. Additionally, vitamin B12 deficiency may occur, making it important to regularly perform blood tests to monitor the condition. It is advisable not to use this medicine in pregnant or potentially pregnant women, breastfeeding mothers, and children and adolescents under 18 years of age. Elderly patients may have reduced kidney function, so dosage adjustments and regular kidney function tests are necessary. Possible adverse effects during use include diarrhea, nausea, vomiting, headache, upper respiratory infection, and if severe joint pain or skin reactions occur, inform a doctor immediately. In case of overdose, general treatment can be applied and, if necessary, the drug can be removed through blood dialysis. Finally, this medicine may interact with other drugs, so it is important to consult healthcare professionals about all medications being taken, especially when used with drugs affecting kidney function.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, exfoliative skin diseases (including Stevens-Johnson syndrome), severe allergic reactions, acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing pancreatitis), acute renal failure, worsening renal function, difficulty breathing, acute or chronic metabolic acidosis (including lactic acidosis) and coma, severe hypoglycemia with disabling symptoms, liver dysfunction (elevated liver enzyme levels, symptoms related to jaundice are explicitly mentioned)

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medicine should be stored in a tightly sealed container to prevent air from entering, at a temperature between 1 to 30 degrees Celsius. This helps to maintain its effectiveness and prevent deterioration.

Appearance

Pink oval film-coated tablet

Package unit

56 tablets/PTP