Clarithromycin Tablets 250mg (Clarithromycin)

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) per dose, twice daily. For severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer this medicine to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose, twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) per dose three times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

○ Children 12 years of age and older: Same as adults. ○ Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be administered to certain patients. First, those who are allergic to any of the ingredients contained in this medication should not take it. Moreover, patients who have previously shown hypersensitivity to antibiotics of a similar class should also refrain from using it. Patients taking heart-related medications, especially those that may affect heart rhythm, should use caution as concurrent use may be hazardous. Patients with severely impaired liver or kidney function should not take this medication, and pregnant or breastfeeding women should also avoid it. This medication should be used cautiously in patients with impaired liver or kidney function, those with heart disease, the elderly, and those taking other antibiotics. A history of allergy or sensitivity to certain dyes contained in this medication also requires caution. This medication may rarely cause various side effects, including severe allergic reactions, skin rashes, gastrointestinal problems, respiratory abnormalities, blood abnormalities, central nervous system symptoms, and liver and kidney dysfunction. If any of these symptoms occur, immediately discontinue the medication and consult a physician. Additionally, this medication may interact with other drugs; therefore, it is crucial to inform healthcare providers about any medications being taken. Particularly when taken with drugs affecting heart rhythm or those metabolized by the liver, more caution is warranted. During pregnancy or breastfeeding, it is safest to avoid this medication, and if it is absolutely necessary to take it, consult with a healthcare professional beforehand. In children, there is limited research on the safety and efficacy of this medication, so a consultation with a physician prior to use is mandatory. Elderly patients may experience increased drug concentration due to decreased bodily functions, necessitating careful dosage adjustment and monitoring. While taking this medication, it is crucial to undergo regular tests on liver and kidney functions, blood tests, and heart condition to monitor for any abnormalities. In case of overdose, gastrointestinal disturbances or mental symptoms may occur, so immediate contact with healthcare professionals is essential for proper management. This medication's absorption or efficacy may change when taken with other drugs, thus adherence to precautions during administration is critical, and storage should be in a cool place, protected from light.

Shock, anaphylactic symptoms, dyspnea, convulsions, erythema, rash, itching, hives, skin erythema, angioedema, joint swelling, drug eruption, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, appetite loss, constipation, discoloration of stool, membrane colitis, hemorrhagic colitis, fever, cough, chest X-ray abnormalities, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute exacerbation of maxillary sinusitis, leukopenia, thrombocytopenia, pancytopenia, hemolytic anemia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de Pointes, malaise, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, hearing impairment, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis, muscle spasms, musculoskeletal stiffness, myopathy, increased serum creatinine, increased blood urea, nephritis, phlebitis at the injection site, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urine color, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schönlein purpura, cardiac arrest, atrial fibrillation, premature contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism

This medication is sensitive to light and should be stored in a place not exposed to light. The storage temperature should be maintained between 1 to 30 degrees Celsius at room temperature, and it is important to store it in a tightly sealed container to prevent air exposure.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle