Sitam 50/500 mg Tablets

Adult dose

In antidiabetic therapy, the dosage of this medication is determined based on each component's daily maximum recommended dosage of sitagliptin 100 mg and metformin 2000 mg, considering each patient's current therapeutic regimen, efficacy, and tolerability. This medication is generally taken twice a day with meals, with gradual dosage escalation to reduce gastrointestinal adverse effects caused by metformin. 1. Metformin

This medication is used to treat diabetes, and patients should be cautious as serious allergic reactions may occur during use. If skin rash, shortness of breath, or swelling of the face or lips occurs, discontinue use immediately and consult a doctor. Acute pancreatitis, an inflammation of the pancreas, may develop, so if abdominal pain, vomiting, or severe indigestion symptoms occur after taking this medication, seek medical attention immediately. This medication should not be used in patients with impaired kidney function, severe heart disease, liver dysfunction, or in pregnant or nursing women. Use of this medication should be temporarily discontinued before and after procedures involving iodine contrast agents and should only be resumed once normal kidney function is confirmed. This medication can cause hypoglycemia, especially when taken with other blood sugar-lowering agents, so blood sugar levels should be checked frequently, and symptoms of hypoglycemia should be monitored. Regular meals and exercise should be maintained, and this medication should be temporarily stopped in cases of sudden dehydration, severe infection, or pre/post-surgery. Alcohol intake can increase the risk of serious side effects such as lactic acidosis, so it is advisable to avoid drinking alcohol while on this medication. Regular blood tests should be conducted to monitor kidney function and vitamin B12 levels, and any abnormal symptoms should be discussed with healthcare providers. This medication carries a risk of reduced kidney function in the elderly, so dose adjustments and periodic function tests are necessary. In cases of overdose, immediate medical care should be sought as some drugs may be removed through dialysis. Irregular meals or intense exercise should be avoided during the course of this medication, and potential interactions with other medications should be discussed with healthcare providers.

Serious side effects

Hives, hypersensitivity reactions (anaphylaxis, angioedema), rash, exfoliative skin conditions (Stevens-Johnson syndrome), severe allergic reactions; acute pancreatitis (fatal/non-fatal hemorrhagic or necrotizing pancreatitis), pancreatitis; acute kidney failure, deterioration of kidney function; shortness of breath, respiratory abnormalities; liver abnormalities (including possible elevation of liver enzymes and symptoms related to jaundice); severe headaches, confusion of consciousness, neurological symptoms such as seizures; severe arthralgia associated with disability.

Mild side effects

• Headache
• diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container that allows for proper air circulation, kept at room temperature between 1°C and 30°C. This helps maintain the medication's effectiveness and safety.

Appearance

Pink oval film-coated tablet

Package unit

56 tablets (14 tablets/PTP packaging × 4)