Uritin Tablet (Ranitidine Hydrochloride)

Adult dose

As ranitidine, the typical dosage is 150 mg taken orally twice a day, in the morning and at bedtime. For the treatment of gastric and duodenal ulcers: administer 150 mg orally twice daily or 300 mg once daily at bedtime. Patients with duodenal ulcers may take 300 mg orally twice daily in the morning and at bedtime. For the prevention of ulcers induced by non-steroidal anti-inflammatory drugs, the same method of administration as above should be followed.

Child dose

For children aged 8-18 years, a single dose of 150 mg (2 mg per kg of body weight) may be administered up to twice a day.

This medication should not be used in patients with hypersensitivity to any of the components of this medication. Also, it should not be administered to patients with a history of acute porphyria, as it may trigger acute attacks. In patients with reduced kidney function, the serum concentration of this drug may increase, so adjustment of dose or dosing interval is necessary. Patients with poor liver function should also use this drug cautiously. Patients with a history of hypersensitivity, older adults, and those taking non-steroidal anti-inflammatory drugs should be administered this drug carefully. Especially, since it may mask symptoms of gastric cancer, patients with gastric ulcers or middle-aged persons with recent dyspepsia should confirm malignancy before treatment. Patients with positive Helicobacter pylori gastric and duodenal ulcers require treatment to eradicate the bacteria. This medication may rarely cause hypersensitivity reactions such as anaphylactic shock, hives, angioedema, and rashes, and if any abnormal symptoms occur, usage should be discontinued immediately. Blood-related side effects such as agranulocytosis, leukopenia, and thrombocytopenia may rarely occur, so if symptoms such as fatigue, bleeding, or fever arise, a blood test should be performed. Liver dysfunction may occur, so if jaundice or elevated liver enzyme symptoms develop, treatment should be stopped. Cardiovascular symptoms such as arrhythmias, constipation, nausea, vomiting, abdominal pain, dizziness, drowsiness, and confusion may also occur rarely, so monitoring is necessary. Long-term use of this drug or its use in older adults, patients with chronic lung diseases, or diabetes may increase the risk of pneumonia, so caution is advised. If dizziness or drowsiness occurs, avoid driving or operating dangerous machinery. This medication can interact with other drugs, so particularly when taking anticoagulants, careful monitoring of blood coagulation status is required. Additionally, taking it with sucralfate may reduce absorption; thus, it is advisable to take them with at least a 2-hour interval. Women who are pregnant or may become pregnant, and breastfeeding women, should use this medication cautiously, only when necessary. Safety in children has not been sufficiently confirmed, so caution is needed in its use. Older adults may likely have decreased kidney function, necessitating dose adjustment. Regular blood tests and liver function tests are recommended while taking this medication, as well as kidney function tests. In case of overdose, treatment such as vomiting, gastric lavage, and possibly blood dialysis may be required. Keep this medication out of the reach of children and do not transfer it to another container for safety. This drug may reduce gastric acid secretion and promote bacterial growth in the gastrointestinal tract, so regular examinations including ophthalmological checks are necessary with long-term use.

Serious side effects

• Hives
• angioedema
• anaphylactic shock
• chest pain
• bronchospasm
• hypotension
• severe allergic reactions
• jaundice
• hepatitis
• liver abnormalities (jaundice)

Mild side effects

Rash, fever, hypotension, angioedema, agranulocytosis, elevated serum creatinine, leukopenia, thrombocytopenia, bone marrow suppression, aplastic anemia, hypereosinophilia, hepatic dysfunction (elevated AST, ALT, γ-GTP, ALP), bradycardia, heart block, tachycardia, vasculitis, constipation, nausea, vomiting, abdominal distension, abdominal pain, loss of appetite, diarrhea, dizziness, drowsiness, headache, feeling of heaviness, insomnia, excitement,

This medication may be sensitive to light, so it should be stored in a container that blocks light. Additionally, to keep the medication safe, it is important to store it at room temperature, that is, between 1 degree and 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle