Ronasen Tablets 8 mg (Blonanserin)

Adult dose

Adults: Take 4mg orally twice daily after meals and increase the dose gradually. The maintenance dose is 8∼16mg per day, divided into 2 doses after meals. Because the absorption of this medicine is easily affected by food, it must be taken after meals. Carefully monitor and adjust the dose for each patient so that it is the minimum required dose, and do not exceed the maximum daily dose of 24mg.

This drug may increase the risk of death in elderly patients with dementia, so caution is required. Particularly, it should be used carefully in patients at risk of cerebrovascular disease, and special care is needed if there is a risk of stroke. There is also a risk of venous thrombosis, so risk factors for thrombosis should be assessed and preventive measures taken before and during the use of this medication. Patients in a comatose state, those taking certain central nervous system depressants, and patients currently on specific antifungal or antiviral agents should not use this medication. Patients with hypersensitivity to this drug or genetic issues such as lactose intolerance should also avoid administration. Careful administration is required for patients with cardiovascular disease, Parkinson’s disease, epilepsy, or a risk of suicide, and attention is needed for patients with impaired liver function. Diabetic patients or those at risk of hyperglycemia should have their blood sugar levels checked regularly. Due to the lack of established safety in pregnant or nursing women and children, administration should be approached with caution. This drug can cause serious side effects such as neuroleptic malignant syndrome, tardive dyskinesia, paralytic ileus, and syndrome of inappropriate antidiuretic hormone secretion, so if any unusual symptoms occur, contact a doctor immediately. Additionally, varied side effects such as hypotension, insomnia, drowsiness, dizziness, gastrointestinal symptoms, and blood abnormalities may occur, requiring careful monitoring during administration. Caution is also necessary as drowsiness or decreased attention may occur during driving or operating machinery. This drug has significant interactions with certain medications, so if taking other drugs, consult with a doctor or pharmacist. In particular, co-administration with drugs that inhibit or induce CYP3A4 enzyme may increase the risk of side effects due to changes in blood concentration. The likelihood of adverse reactions is higher in the elderly, so administration should be done cautiously with close monitoring.

Increased mortality, cerebrovascular disease, venous thrombosis, worsening of coma, enhanced central nervous system depression, neuroleptic malignant syndrome, catatonia, muscle rigidity, dysphagia, tachycardia, blood pressure fluctuations, sweating, altered consciousness, dyspnea, circulatory collapse, dehydration, acute kidney injury, delayed motor impairment, involuntary movements of the perioral muscles, paralytic ileus, decreased appetite, nausea, vomiting, diarrhea, abdominal distension, lethargy, syndrome of inappropriate antidiuretic hormone secretion, hyponatremia, hypotonicity, urinary sodium hypersecretion, hyperuricemia, convulsions, rhabdomyolysis, myalgia, weakness, elevated CK, agranulocytosis, leukopenia, liver dysfunction, elevated AST, elevated ALT, elevated γ-GTP, elevated ALP, elevated bilirubin, hyperglycemia, diabetic ketoacidosis, diabetic coma, eosinophilia, rash, eczema, pruritus, hypotension, orthostatic hypotension, hypertension, electrocardiogram abnormalities, tachycardia, bradycardia, arrhythmia, ventricular extrasystoles, loss of control extrasystoles, palpitations, decreased heart rate, Parkinson's syndrome, tremors, muscle rigidity, hypersalivation, akinesia, bradykinesia, gait disturbance, mask-like face, inability to sit still, dyskinesia, dysarthria, involuntary movements of oral muscles, abnormal muscle tone, rigid neck, facial spasms, pharyngeal spasms, uterine spasms, ocular motor crisis, camptocormia, fatty liver disease, control disorders, blurred vision, photophobia, constipation, decreased appetite, gastritis, gastroenteritis, increased appetite, diarrhea, epigastric pain, abdominal pain, gastrointestinal disorder, cheilitis, elevated prolactin, menstrual irregularities, galactorrhea, sexual dysfunction, gynecomastia, erectile dysfunction, dysuria, urinary retention, incontinence, polyuria, insomnia, drowsiness, anxiety, agitation, anger, dizziness, lightheadedness, dull headache, headache, excitement, aggression, nightmares, exacerbation of schizophrenia, over-sedation, over-inhibition, depression, hallucinations, auditory hallucinations, delusions, paranoid delusions, sleep disturbances, abnormal behavior, hyperactivity, suicide attempts, abnormal EEG, manic state, altered consciousness, emotional disturbances, tingling in hands and feet, speech impairment, talkativeness, tension, convulsions, leukocytosis, neutrophilia, leukopenia, lymphocytopenia, erythrocytosis, anemia, erythropenia, decreased hemoglobin, decreased hematocrit, thrombocytosis, thrombocytopenia, atypical lymphocytes, generalized fatigue, thirst, weakness, edema, water intoxication, hair loss, diabetes, hypoglycemia, upper respiratory tract infection, nasopharyngitis, limb pain, sweating, fever, weight gain, weight loss, chest pain, cough, hyperventilation, rhinorrhea, epistaxis, next, facial edema, aspiration pneumonia, hypothermia, elevated CK, increased triglycerides, elevated blood cholesterol, increased plasma insulin, increased plasma phospholipids, elevated blood glucose, increased BUN, decreased BUN, decreased total plasma protein, increased plasma potassium, decreased plasma potassium, decreased plasma sodium, positive urine protein, positive urine urobilinogen, positive urine glucose, positive urinary occult blood, thrombosis, epidermal necrolysis, lethargy

This medication should be stored in a tightly closed container to avoid exposure to air and moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. Avoid storing in excessively hot or cold places.

Appearance

White round tablets

Package unit

30 tablets/bottle, 100 tablets/bottle