Duo-Tablet 5/1000 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dosage is 10 mg of Dapagliflozin / 2000 mg of extended-release Metformin once daily, given as 2 tablets of 5 mg / 1000 mg. In cases without prior experience of diabetes medication, the initial regimen is to take one tablet of 5 mg / 500 mg or 10 mg / 500 mg once daily. To reduce gastrointestinal side effects of Metformin, the dosage should be titrated.

This medication is used for the treatment of diabetes and helps control blood sugar. However, this medication can very rarely cause a dangerous condition called severe lactic acidosis, thus caution is advised. When used with other diabetes medications, hypoglycemic symptoms may occur, so it should be used with care. It should not be administered to patients with poor kidney function, dehydration, severe infections, or heart problems. Pregnant or breastfeeding women, as well as patients with certain genetic disorders, should not use this medication. Elderly patients or those with impaired kidney function should have their kidney function regularly tested while using this medication, and their fluid status should be closely monitored. Genital infections or urinary tract infections can occur during the use of this medication, so if symptoms arise, consult a physician immediately. Also, hypoglycemic symptoms may occur, so dosage adjustment may be necessary when used in conjunction with insulin or sulfonylureas. This medication can lower vitamin B12 levels, so long-term users are advised to undergo vitamin B12 testing. Alcohol consumption can increase the risk of lactic acidosis, so excessive drinking should be avoided while on this medication. Before surgery or radiation tests, this medication should be temporarily discontinued, and it should be restarted only after confirming normal kidney function. In cases of overdose, seek medical attention immediately for appropriate treatment, and dialysis may be required. This medication should be kept out of reach of children and stored in its original container for safety. Caution is advised while driving or operating machinery, as dizziness may occur.

Serious side effects

• Severe lactic acidosis
• severe hypoglycemia
• dehydration
• hypovolemia
• hypotension
• diabetic ketoacidosis
• urosepsis
• pyelonephritis
• acute kidney injury
• renal impairment

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, thirst, dizziness, constipation, dry mouth, low back pain, pain during urination, polyuria, nocturia, genital and vulvar itching, increased hematocrit, decreased creatinine clearance at the start of treatment, dyslipidemia, increased serum creatinine in the early stages of treatment, elevated blood urea, weight loss, diarrhea, nausea/vomiting, reduced vitamin B12 levels/deficiency, abdominal pain

This medication should be stored in a tightly closed container to protect it from air and moisture. Additionally, it is best stored at room temperature between 1°C and 30°C, avoiding very hot or very cold places.

Appearance

Pink to dark pink, biconvex, oval film-coated tablets

Package unit

30 tablets (6 tablets x 5) / box