Vtikoconazole Tablets (Itraconazole Solid Dispersion)

Adult dosage

It is preferable to administer this product immediately after a meal to increase absorption. 1. Short-term treatment This product has a persistent therapeutic effect in skin tissue even after discontinuation. Therefore, final clinical and mycological outcomes should preferably be assessed 2～4 weeks after completion of the prescribed treatment. 1) Vulvovaginal candidiasis: Administer itraconazole 200mg twice daily (morning and evening) for 1 day, or 200mg once daily for 3 days. 2) Pityriasis versicolor: Administer 200mg once daily for 7 days. 3) Tinea corporis, tinea cruris (jock itch): Administer 100mg once daily for 15 days. 4) Tinea manuum (interdigital type), tinea pedis (interdigital type): Administer 100mg once daily for 15 days. 5) Tinea manuum (palmar), tinea pedis (plantar): Administer 100mg once daily for 30 days or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by a 3-week drug-free period; this constitutes one cycle. Administer up to 2 cycles for infection of the fingernails only and up to 3 cycles for infection of the toenails. Site of onychomycosis Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Toenails (with or without concomitant fingernail infection) Treatment Drug-free Treatment Drug-free Treatment Fingernails Treatment Drug-free Treatment or 2) Continuous therapy Administer 200 mg once daily for 3 months. The therapeutic effect continues for 3 months after treatment ends for fingernails and 6 months for toenails. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplant recipients, the oral bioavailability of this product may be reduced; therefore, the dose may be doubled if necessary. Aspergillosis: 200mg once daily, mean treatment duration 2～5 months. For invasive or disseminated disease, increase to 200mg twice daily. Candidiasis: 100～200mg once daily, mean treatment duration 3 weeks～7 months. Cryptococcal meningitis: 200mg twice daily, mean treatment duration 2 months～1 year. Maintenance therapy: 200mg once daily. Paracoccidioidomycosis: 100mg once daily, mean treatment duration 6 months

This medication can be life-threatening for patients with impaired cardiac function, especially those with congestive heart failure, and should only be administered under a doctor's judgment. Avoid taking this medication if you have an allergic reaction to it or have certain heart conditions, and when taking with specific drugs it may pose risks. Pregnant women or those who may become pregnant, as well as breastfeeding women, should not take this medication and should use effective contraceptive methods after taking it. Those with impaired liver or kidney function should regularly check their liver and kidney function when taking this medication, and dose adjustments may be necessary if needed. This drug can interact with various medications, so if you are taking any other medications, be sure to inform your doctor or pharmacist, as some medications are contraindicated for use together. During treatment with this medication, you may experience gastrointestinal symptoms such as headaches, nausea, abdominal pain, diarrhea, as well as neurological symptoms like dizziness and drowsiness, so if symptoms are severe, consult your healthcare provider. Rarely, hearing loss, cardiac side effects, liver dysfunction, and allergic reactions may occur, so if any abnormal symptoms are present, treatment should be discontinued immediately and healthcare professionals should be informed. This medication's absorption may be reduced in low acidity conditions, so if taking acid-reducing medications, it is recommended to take it with acidic beverages. The safety of this medication has not been sufficiently verified in children or the elderly, so extra caution is needed when administering it. In case of overdose, there is no specific antidote, so appropriate treatment according to symptoms is crucial and this medication is not removed by hemodialysis. Finally, this medication should be kept out of the reach of children and stored in its original container to prevent deterioration in quality or misuse.

Headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory tract infection, leukopenia, hypersensitivity, taste disorder, sensory impairment, paresthesia, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual disorder, edema, agranulocytosis, thrombocytopenia, anaphylactoid reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, altered mental status, peripheral neuropathy, dizziness, drowsiness, tremor, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, speech disorder, cough, gastrointestinal disorder, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, renal dysfunction, incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, elevated serum urea, elevated gamma-glutamyl transferase, increased liver enzymes, abnormal urinalysis, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, angioneurotic edema, anaphylaxis, anaphylactic shock, allergic reaction, double vision, visual impairment, hearing loss, ventricular ectopy, atrioventricular block, palpitations, increased bowel motility, belching, glossitis, stomatitis, abdominal and lumbar pain, pancreatitis, elevated serum total protein, elevated total bilirubin, elevated LAP, loss of appetite, malaise, brown urine, mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Lele syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, elevated BUN, positive urine protein, positive urine glucose, decreased libido, drowsiness, malaise, shoulder stiffness, insomnia, chest pain, elevated serum triglycerides, burning sensation, elevated serum uric acid, elevated serum potassium, serum sickness, angioneurotic edema, anaphylactic reaction, hyperlipidemia, tremor, visual impairment, transient hearing loss, permanent hearing loss, congestive heart failure, dyspnea, pancreatitis, significant hepatotoxicity, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitive, increased serum creatine phosphokinase

This medication should be stored in a tightly sealed container to prevent air ingress, and it should be safely stored at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain its effectiveness for a long time.

Appearance

White or pale yellow round film-coated tablets

Package unit

28 tablets/bottle