Vildagliptin Tablets 100 mg (Sitagliptin Phosphate Hydrate)

Adult dose

The drug is administered once daily at a dose of 100 mg in monotherapy or in combination therapy, with a maximum daily dose of 100 mg. This drug can be taken regardless of meals. For patients with renal impairment, dosage adjustment is required based on kidney function. - Mild renal impairment (eGFR 60–90 mL/min/1.73 m2): no dosage adjustment needed. - Moderate renal impairment (eGFR 45–60 mL/min/1.73

This medication can cause serious allergic reactions in some patients. If symptoms such as skin rash or difficulty breathing occur within 3 months of administration, discontinue immediately and consult a doctor. During the use of this medication, serious pancreatic inflammation, known as pancreatitis, may occur, so immediate notification to healthcare professionals is necessary in cases of severe abdominal pain or vomiting. This medication should not be used in patients with type 1 diabetes or those with diabetic ketoacidosis, and patients with known allergies to this drug or any of its components should also avoid its use. Patients with impaired renal function should adjust the dosage of this medication, so regular kidney function tests should be conducted and it should be taken according to the doctor's instructions. During treatment, symptoms similar to a cold or headaches may occur, and some patients may experience hypoglycemic symptoms; therefore, it is important to monitor blood sugar levels periodically. When taken with other hypoglycemic agents like insulin or sulfonylureas, the risk of hypoglycemia may increase, so dosage adjustments may be required. This medication is not recommended for use in pregnant or breastfeeding women, nor has its safety and efficacy been established in children or adolescents under 18 years of age. Older adults may have reduced renal function, so renal function should be assessed prior to use, and regular assessments should continue during treatment. In case of overdose, symptomatic treatment will be provided, and if necessary, some medications may be removed via hemodialysis. If blisters appear on the skin or severe joint pain occurs during use, report immediately to a physician and discontinue treatment. Generally, interactions with other medications are minimal, but the blood concentration may vary slightly when taking certain medications, so inform a doctor or pharmacist before use. In general, this medication does not increase cardiovascular risk, but if there is a history of cardiovascular disease, regular check-ups are necessary.

Serious side effects

Severe allergic reactions (including rash and angioedema), anaphylaxis, exfoliative skin diseases such as Stevens-Johnson syndrome, acute pancreatitis, severe allergic reactions (including rash, severe swelling, tightness in the chest, difficulty breathing, cold sweat, paleness), severe skin reactions (severe rash, blistering, skin peeling, pain in mucous membranes of the mouth/eyes), respiratory problems (including shortness of breath or difficulty breathing, asthma attacks, coughing)

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• constipation
• vomiting
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a tightly closed container to prevent entry of air, ideally at room temperature between 1 to 30 degrees Celsius. Proper storage will maintain the efficacy of the medication and prevent degradation.

Appearance

Beige, round, bilaterally convex film-coated tablet

Package unit

30 tablets/bottle