Hanubi Tablet 50mg (Sitagliptin Phosphate)

Adult dose

This medication is administered once daily at a dosage of 100 mg, whether used alone or in combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. For patients with renal impairment, dosage adjustment is necessary based on renal function. - Mild renal impairment (eGFR 60-90 mL/min/1.73 m2): No dosage adjustment needed - Moderate renal impairment (eGFR 45-60 mL/min/1.73 m2):

This medication may cause severe allergic reactions in some patients. If symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur after taking the medication, stop using it immediately and consult a doctor. While taking this medication, monitor carefully for symptoms of pancreatitis, which is inflammation of the pancreas, including severe abdominal pain, nausea, or vomiting. If such symptoms are suspected, discontinue use of this medication immediately and inform healthcare personnel. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and it should not be administered to individuals with a known allergy to this medication or its components. In patients with impaired kidney function, the excretion of this medication may slow down, thus dosage adjustments should be made based on renal function test results. In particular, it is recommended to administer lower doses to end-stage renal patients undergoing dialysis. This medication can be used alone or in combination with other diabetes treatments; however, when taken alongside insulin or sulfonylureas, the risk of hypoglycemia may increase, so closely monitor changes in blood sugar levels. Common side effects reported in clinical trials include upper respiratory infections, nasopharyngitis, headaches, diarrhea, and abdominal pain, most of which are mild or transient. If severe joint pain or skin blisters occurs while taking this medication, inform a doctor immediately and discontinue the use of the medication. Women who are pregnant or breastfeeding are advised against its use due to uncertain safety. Safety and efficacy have not been established in children and adolescents under 18 years of age. Elderly patients are at a higher risk for decreased kidney function; therefore, assessment of renal function before administration of this medication and dosage adjustments are necessary. In the event of overdose, symptomatic treatment is generally implemented. This medication can be partially removed through hemodialysis, so consider hemodialysis if needed. This medication has not shown significant interactions when taken with several other medications, but it is advisable to consult healthcare personnel if it is to be taken with certain drugs. If unexpected symptoms or side effects occur while taking this medication, immediately inform healthcare personnel and obtain appropriate medical care.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, Stevens-Johnson syndrome, severe rash, blisters, skin peeling, pain in oral/ocular mucosa, acute pancreatitis, severe skin adverse reactions, acute renal failure, severe joint pain accompanied by disability, vesicular pemphigoid, severe allergic reactions, liver abnormalities (jaundice), severe neurological symptoms, severe swelling or urinary abnormalities

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a sealed container and kept at room temperature between 1 degree and 30 degrees Celsius. Proper storage maintains the efficacy of the medication and ensures safe usage.

Appearance

Light beige, double convex, round film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP 3 pieces)]