Sitafage 50/500 mg (Sitagliptin Phosphate, Metformin Hydrochloride)

Adult dose

In antidiabetic therapy, the dosage of this medication should not exceed the daily maximum recommended doses of sitagliptin 100 mg and metformin 2000 mg, and it should be determined considering each patient's current treatment regimen, efficacy, and tolerability. This medication is generally taken twice a day with food, and the dosage should be gradually increased to minimize gastrointestinal adverse reactions caused by metformin. 1. Patients who are currently not being treated with metformin

This medication is used for diabetes treatment and contains both sitagliptin and metformin. First, serious allergic reactions may occur during the use of this medication, so if symptoms such as skin rash, swelling, or difficulty breathing occur, stop taking the medication immediately and consult a doctor. Second, this medication can cause serious side effects such as pancreatitis, which is inflammation of the pancreas, so if sudden abdominal pain, nausea, vomiting, or fever occurs, inform healthcare professionals immediately. Third, metformin can cause lactic acidosis, a rare but life-threatening metabolic disorder, so if you experience sudden weakness, shortness of breath, muscle pain, abdominal pain, or unusual changes in consciousness, stop taking this medication immediately and visit a hospital. Fourth, patients with severely decreased kidney function, severe infections, dehydration, heart failure, or acute myocardial infarction should not take this medication, and it should be temporarily discontinued before and after undergoing tests with iodine contrast agents. Fifth, it is advisable for pregnant women or those who might become pregnant, as well as nursing mothers, not to take this medication. Sixth, this medication can cause hypoglycemia, so caution is needed, especially if meals are skipped or irregular, rigorous exercise is performed, or it is used in combination with other antidiabetic medications. Seventh, it is important to regularly monitor kidney function and blood tests during the use of this medication, and since vitamin B12 deficiency may occur, supplementation may be necessary if needed. Eighth, the consumption of alcohol may increase the risk of side effects from this medication, so it is recommended not to consume excessive amounts of alcohol while taking it. Lastly, blistering skin diseases or severe joint pain may occur during the use of this medication. If these symptoms appear, consult a doctor immediately.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, breathing difficulties, anaphylaxis, Stevens-Johnson syndrome, severe skin adverse reactions, acute pancreatitis, acute renal failure, respiratory distress, severe and disabling arthralgia, bullous pemphigoid, rhabdomyolysis, liver abnormalities (elevated liver enzyme levels, jaundice), severe edema, acute renal failure, severe allergic reactions, severe hypoglycemia

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infections
• nasopharyngitis
• headache
• hypoglycemia
• constipation
• weakness

This medication should be stored in a tightly sealed container to prevent air exposure, and it is advisable to keep it at a temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's efficacy over time.

Appearance

Bright pink oval film-coated tablet

Package unit

30 tablets/box [10 tablets/PTPX3]