Esomeprazole Magnesium Hydrate Capsule 20mg

Adult dosage

Adults Gastroesophageal reflux disease (GERD) Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. If esophagitis has not healed or symptoms persist, continue treatment for an additional 4 weeks. Long-term maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily Symptomatic treatment of gastroesophageal reflux disease without esophagitis: 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is necessary. Once symptoms have resolved, subsequent recurrent symptoms may be controlled with 20 mg once daily. In adults, 20 mg once daily may be taken as needed. As-needed treatment to control recurrent symptoms is not recommended for patients at high risk of developing gastric or duodenal ulcers due to nonsteroidal anti-inflammatory drug use. Combination therapy with antibiotics for eradication of Helicobacter pylori Administer this drug 20 mg in combination with amoxicillin 1 g and clarithromycin 500 mg twice daily for 7 days. Short-term treatment of upper gastrointestinal symptoms (pain, discomfort, heartburn) associated with the use of nonsteroidal anti-inflammatory drugs (nonselective or selective COX-2 inhibitors) 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is necessary. Clinical studies extending beyond 4 weeks have not been conducted. Patients requiring continued nonsteroidal anti-inflammatory drug treatment Treatment of gastric ulcers associated with nonsteroidal anti-inflammatory drug use: 20 mg once daily. The treatment duration is 4∼8 weeks. Prevention of gastric and duodenal ulcers associated with nonsteroidal anti-inflammatory drug use: 20 mg once daily. Treatment of Zollinger-Ellison syndrome The recommended initial dose is 40 mg twice daily. The dose should subsequently be adjusted for each patient, and treatment should continue for as long as clinical symptoms are present. Clinical data indicate that most patients can be controlled with doses of 80 ∼ 160 mg per day. Doses exceeding 80 mg per day should be divided and taken twice daily. Maintenance therapy following intravenous induction of prevention of rebleeding from gastric or duodenal ulcers After intravenous induction of prevention of rebleeding from gastric or duodenal ulcers, administer 40 mg once daily for 4 weeks. Renal impairment No dose adjustment is necessary. Use with caution because experience with administration to patients with severe renal impairment is limited. Hepatic impairment No dose adjustment is necessary in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the dose of this drug should not exceed 20 mg. Elderly patients No dose adjustment is necessary.

Children's dosage

Adolescents aged 12 years and older — Gastroesophageal reflux disease (GERD), treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. If esophagitis has not healed or symptoms persist, continue treatment for an additional 4 weeks. Adolescents aged 12 years and older — Gastroesophageal reflux disease (GERD), symptomatic treatment of gastroesophageal reflux disease without esophagitis: 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is necessary. Adolescents aged 12 years and older — Gastroesophageal reflux disease (GERD), symptomatic treatment of gastroesophageal reflux disease without esophagitis: Once symptoms have resolved, subsequent recurrent symptoms may be controlled with 20 mg once daily. Children under 12 years of age — There is no experience with administration of this drug to children under 12 years of age.

This medication should not be used in certain patients. Patients who are allergic to this medication, its components, or benzimidazole derivatives should not be administered this. Also, patients who are allergic to penicillin-type or macrolide antibiotics should not use this when combining it with amoxicillin or clarithromycin for the eradication of Helicobacter pylori. Furthermore, patients taking certain heart-related medications, antiviral agents, or nursing mothers should not take this medication. Various adverse reactions may occur while taking this medication. Blood-related issues such as leukopenia and thrombocytopenia may occur infrequently, and immune system reactions such as allergic reactions or anaphylaxis have also been reported. Electrolyte imbalances like hypomagnesemia and hyponatremia may occur infrequently, and symptoms such as insomnia, anxiety, and depression may also occur. Neurologic symptoms such as headache, dizziness, and taste disorders are reported relatively frequently. Gastrointestinal reactions such as abdominal pain, diarrhea, nausea, and vomiting may occur commonly, and in severe cases, pancreatitis or gastrointestinal infections may occur. Furthermore, skin-related adverse reactions such as rash, itching, and hair loss may also occur. This medication can mask symptoms of malignant tumors or delay diagnosis, therefore patients suspected of cancer among gastric ulcer patients should consult with a specialist. Regular examinations are required for long-term use, especially beyond one year, and consultation with a physician is necessary if any changes in symptoms occur. This medication can suppress gastric acid secretion, potentially leading to bacterial overgrowth in the stomach, increasing the risk of gastrointestinal infection. Additionally, long-term use may increase the risk of fractures, therefore caution is needed in patients at risk of osteoporosis. Hypomagnesemia may develop after more than three months of use, and regular checks of magnesium levels are required. This medication has many interactions with other drugs, so if you are taking other medications, be sure to inform your doctor or pharmacist and exercise caution. Particularly, when taken with antibiotics, antiviral agents, anticoagulants, anticonvulsants, etc., there may be an increased risk of side effects due to shifts in drug concentrations, so monitoring is necessary. Care should be taken while using this medication during pregnancy, and it is recommended not to take this if nursing. In case of overdose, there are no specific antidotes, and treatment should be supportive and symptomatic. This medication should be stored out of reach of children and care should be taken not to transfer it to another container as this may negatively affect quality.

Leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, fever, angioedema, anaphylactic reactions, shock, peripheral edema, hyponatremia, hypomagnesemia, insomnia, anxiety, mental confusion, depression, aggressiveness, hallucinations, headache, dizziness, paresthesia, drowsiness, taste disorders, blurred vision, bronchospasm, pancreatitis, abdominal pain, constipation, diarrhea, abdominal distension, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, microscopic colitis, increased liver enzymes, jaundice, hepatitis, liver failure, encephalopathy, dermatitis, itching, rash, hives, hair loss, photosensitivity, erythema multiforme, mucosal membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, eosinophilia with systemic drug reactions, fractures, arthralgia, myalgia, muscle weakness, nephritis, gynecomastia, asthenia, increased sweating, Clostridium difficile-associated diarrhea, abdominal bloating, allergic reactions, back pain, chest pain, sternal pain, facial edema, facial flushing, fatigue, influenza-like illness, general edema, leg edema, lethargy, pain, stiffness, peripheral edema, flushing, hypertension, tachycardia, thyroid enlargement, irritable bowel syndrome, exacerbation of constipation, dyspepsia, dysphagia, gastrointestinal malformation, upper abdominal pain, belching, esophageal disorders, frequent bowel movements, gastroenteritis, gastrointestinal bleeding, hiccups, melena, oral disorders, pharyngeal disorders, rectal disorders, gastrointestinal symptoms, increased serum gastrin, tongue disorders, tongue swelling, ulcerative stomatitis, earache, tinnitus, anemia, hypopigmented anemia, cervical lymphadenopathy, epistaxis, leukocytosis, leukopenia, thrombocytopenia, hyperbilirubinemia, abnormal liver function, increased ALT, increased AST, diabetes, hyperuricemia, increased ALP, thirst, vitamin B12 deficiency, weight gain, weight loss, exacerbation of arthritis, arthropathies, cramps, fibromyalgia syndrome, hernia, rheumatologic polymyalgia, anorexia, apathy, increased appetite, confusion, worsening of depression, hypertonia, sensory loss, erectile dysfunction, insomnia, migraine, exacerbation of migraine, sleep disorders, tremor, visual field defects, dysmenorrhea, menstrual disorders, vaginitis, exacerbation of asthma, cough, dyspnea, laryngeal edema, pharyngitis, rhinitis, sinusitis, acne, anal itching, erythematous rash, papular rash, otitis media, abnormal olfaction, loss of taste, taste distortion, urinary abnormalities, albuminuria, cystitis, dysuria, fungal infection, hematuria, urinary frequency, candidiasis, genital candidiasis, polyuria, conjunctivitis, visual disturbances, duodenitis, esophagitis, esophageal stricture, esophageal ulcer, esophageal varices, gastric ulcer, gastritis, benign polyps or nodules, Barrett's esophagus, mucosal discoloration, hernia, systemic lupus erythematosus, cutaneous lupus erythematosus, gastric fundic polyps, hypocalcemia, hypokalemia, rhabdomyolysis

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius. Storing this way helps to preserve the efficacy of the medication.

Appearance

A hard capsule with a light green upper part and a pale yellow lower part, containing round pellets that are light yellow to light gray in color.

Package unit

28 capsules/bottle