Sitagliptin Tablet 25mg (Sitagliptin Phosphate Hydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg for monotherapy or combination therapy, with a maximum daily dose of 100 mg. This medication can be taken without regard to meals. Patients with renal impairment may require dose adjustments based on their kidney function. 1. In patients with mild renal impairment (eGFR 60–90), dose adjustments are not necessary. 2. In patients with moderate renal impairment (eGFR 45–60), dose adjustments are not necessary.

This medication may cause severe allergic reactions after administration; therefore, if symptoms such as skin rash or difficulty breathing occur, use should be discontinued immediately and consultation with a physician is required. If symptoms of acute pancreatitis such as severe abdominal pain or vomiting develop while taking this medication, medical personnel should be notified immediately, and the medication should be stopped in such cases. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication, and individuals who have experienced severe allergic reactions to this medication or its components should avoid taking it. Patients with impaired kidney function may require dose adjustments for this medication, so kidney function tests should be conducted before administration, and the medication should be taken following a physician's instruction. In clinical trials, mainly mild adverse reactions were reported, with common symptoms including upper respiratory infections, headaches, nasopharyngitis, and diarrhea. The risk of hypoglycemia may increase when used with other blood sugar-lowering agents; therefore, care should be taken for signs of hypoglycemia and dosage may need to be adjusted when used alongside insulin or sulfonylureas. If severe joint pain or skin blisters occur during treatment with this medication, consultation with a physician should be sought immediately to receive appropriate measures. It is recommended that women who are pregnant or breastfeeding do not use this medication, and safety for children and adolescents under 18 years has not been established. In the case of overdose, immediate medical attention should be sought, as this medication can be partially eliminated through hemodialysis. This medication has relatively few interactions with other drugs, but caution is required when used in combination with certain medications, so if other medications are being taken, the physician should be informed. Elderly patients may have decreased kidney function, so it is important to adjust the dosage of this medication and regularly check kidney function.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweats, paleness, severe allergic reactions, severe rashes with high fever, blisters, peeling skin, mucosal pain in the mouth/eyes, Stevens-Johnson syndrome and exfoliative skin diseases, shortness of breath or respiratory distress, asthma attacks, abnormal breathing accompanied by coughing, yellowing of skin or eyes (jaundice), acute pancreatitis (hemorrhagic or necrotizing pancreatitis), sudden onset

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Pink, round, biconvex film-coated tablet

Package unit

Company packaging unit