Caresil 5mg (Solifenacin Succinate)

Adult dose

The usual recommended dose for adults (including the elderly) is 5mg once daily. If necessary, the dose may be increased to a maximum of 10mg once daily. This drug may be taken regardless of meals and should be swallowed whole with water. Dosage adjustment is required for the following patients. 1. Patients with renal impairment No dose adjustment is necessary in patients with mild or moderate renal impairment (creatinine clearance>30ml/min). In patients with severe renal impairment (creatinine clearance≤30ml/min), administer with caution and do not exceed 5mg once daily. 2. Patients with hepatic impairment No dose adjustment is necessary in patients with mild hepatic impairment. In patients with moderate hepatic impairment (Child-Pugh class B), administer with caution and do not exceed 5mg once daily. 3. Patients taking strong cytochrome P450 3A4 (CYP3A4) inhibitors In patients taking ketoconazole or another strong CYP3A4 inhibitor (e.g., ritonavir, nelfinavir, itraconazole), limit the maximum daily dose to 5mg.

This medication is used to relieve the symptoms of overactive bladder by controlling bladder muscles. It should not be used in patients with urinary retention symptoms where urine cannot be discharged well. Patients with severe gastrointestinal problems, myasthenia gravis, or angle-closure glaucoma should also not take this medication. Patients with allergies to this medication or those undergoing dialysis, as well as those with severe liver or kidney dysfunction, should use caution. Patients who are at risk for urinary retention or have gastrointestinal obstruction or decreased gastrointestinal motility should be prescribed this medication with care. Patients with moderate to severe liver or kidney dysfunction should have their maximum dosage of this medication limited. Particularly when taken in conjunction with strong CYP3A4 inhibitors, dosage adjustments may be necessary, and it should be avoided in patients with certain metabolic disorders. Side effects such as dry mouth, constipation, blurred vision, urinary retention, dry eyes, etc., may occur with this medication. In severe cases, symptoms like bowel obstruction, angioedema, or anaphylactic reactions may occur, and if any unusual symptoms appear, medical consultation should be sought immediately. This medication may cause drowsiness or fatigue, so caution is needed when driving or operating machinery. Taking it with other anticholinergic medications may enhance effects or increase side effects, so care should be taken when combining therapies. Additionally, it may reduce the effectiveness of drugs that promote gastrointestinal motility. Since this medication is primarily metabolized in the liver, patients with liver dysfunction or those taking CYP3A4 inhibitors may experience increased drug concentrations, necessitating dosage adjustments. The safety during pregnancy has not been established, so special precautions are needed; nursing women are advised to avoid using this medication. The safety and effectiveness in pediatric patients have also not been adequately established, so its use is not recommended. In cases of overdose, central nervous system symptoms, blurred vision, dizziness, etc., may occur, and appropriate treatment should be sought immediately. Patients with a history of heart disease or those at risk for QT prolongation should take caution as there is a risk of cardiac side effects in the event of an overdose.

• Dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• nausea
• indigestion
• abdominal pain
• vomiting
• urinary tract infection

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is best to store it at room temperature between 1 and 30 degrees Celsius. This way, the efficacy of the medication can be maintained for a long time.

Appearance

Bright yellow round film-coated tablet

Package unit

100 tablets (10 tablets/PTP×10)