Donepezil Tablet 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Administer 5 mg once daily before bedtime as Donepezil hydrochloride. If unusual dreams, nightmares, or sleep disturbances occur, consider administering this medication in the morning. The concentration of Donepezil reaches a steady state 15 days after administration, and the frequency of adverse reactions can be influenced by the rate of dosage increase, so the 5 mg dosage should be administered for 4 to 6 weeks. Evaluate clinical responses during this period.

This medication contains Donepezil hydrochloride hydrate as the main ingredient and is used to treat symptoms of Alzheimer's dementia. It should not be used in certain patients. For example, individuals with allergies to this medication or its components, pregnant women, or women who may become pregnant, and nursing mothers should avoid taking it. Additionally, as this medication contains lactose, individuals with lactose intolerance or related genetic disorders should not take it. Patients with heart disease, particularly those who may experience bradycardia or arrhythmias, should use this medication with caution, and it is important to monitor their heart condition periodically. Patients with gastrointestinal issues or those taking anti-inflammatory painkillers should be careful as this may exacerbate gastric ulcers or gastrointestinal bleeding. Patients with a history of asthma or obstructive lung diseases should also be cautious, as symptoms may worsen due to bronchoconstriction or increased secretions. Patients with extrapyramidal disorders such as Parkinson's disease may have exacerbated symptoms, so they should consult a doctor before taking this medication. During the use of this medication, various adverse reactions may occur. For example, cardiac-related problems, gastrointestinal bleeding, liver dysfunction, cerebrovascular issues, movement disorders, difficulty breathing, acute pancreatitis, acute renal failure, sudden death have been reported. In addition, various symptoms such as hallucinations, anxiety, insomnia, dizziness, diarrhea, nausea, vomiting, myalgia, rash may occur, and if any abnormal symptoms appear, immediate consultation with a doctor is recommended. This medication is not approved for other forms of memory impairment besides Alzheimer's dementia, and treatment should be initiated and supervised by an experienced physician. Patients with heart disease or a history of QT interval prolongation are at increased risk for cardiac arrhythmias, thus regular ECG monitoring may be necessary. This medication may affect driving or operating machinery, so caution is required when starting the medication or changing the dosage. Pregnant or nursing women should not take this medication, and if absolutely necessary, may need to consult a specialist to discontinue breastfeeding. Safety has not been established in children, so this medication is not used in children. This medication can interact with other drugs, so it's important to inform your doctor or pharmacist, particularly if you are taking drugs that affect CYP3A4 or CYP2D6 enzymes, muscle relaxants, cholinergic drugs, anticholinergic drugs, or cardiovascular medications. In case of overdose, severe symptoms such as nausea, vomiting, bradycardia, hypotension, respiratory depression, muscle weakness can occur, requiring immediate medical attention. Atropine may be used as an antidote. This medication should be stored out of reach of children and should not be transferred to other containers for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusional state, visual disturbances, paralysis, urination

Mild side effects

• Loss of appetite
• nausea
• vomiting
• diarrhea
• headache
• fatigue
• dizziness
• insomnia
• drowsiness
• hallucinations

This medication should be stored in a tightly closed container to protect it from air and moisture. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle