Ditra Tablet (Itraconazole Solid Dispersion)

Adult dosage

It is preferable to administer immediately after a meal. 1. Short-term treatment 1) Vulvovaginal candidiasis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Pityriasis versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis, tinea cruris (jock itch): Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital type), tinea pedis (interdigital type): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palmar), tinea pedis (plantar): Administer 100 mg once daily for 30 days or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by 3 weeks without treatment; this constitutes 1 cycle. Administer up to 2 cycles for fingernail infections only and up to 3 cycles for toenail infections. 2) Continuous therapy Administer 200 mg once daily for 3 months. The therapeutic effect continues for 3 months for fingernails and 6 months for toenails after treatment ends. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplants, the oral bioavailability of this medicine may be reduced; if necessary, double the dose. Aspergillosis: 200mg once daily; average treatment duration 2～5 months. For invasive or disseminated disease, increase to 200mg twice daily. Candidiasis: 100～200mg once daily; average treatment duration 3 weeks～7 months. Cryptococcal meningitis: 200mg twice daily; average treatment duration 2 months～1 year. Maintenance therapy: 200mg once daily. Paracoccidioidomycosis: 100mg once daily; average treatment duration 6 months.

This drug may pose a risk to patients with impaired cardiac function or a history of heart failure, and should not be administered unless for life-threatening infections. Treatment should be discontinued immediately if signs of congestive heart failure appear. Patients with hypersensitivity to this drug, those with specific cardiac, renal, or liver diseases, pregnant or breastfeeding women should not take this medication. Additionally, this drug has significant interactions with various medications, so consultation with a doctor or pharmacist is essential if taken with specific drugs. Patients with reduced liver function may be affected by the metabolism of this drug and should undergo regular liver function tests, with dosage adjustments if necessary. Caution is also advised when administering to patients with reduced kidney function, considering dosage adjustments. Rarely, serious side effects such as liver damage, allergic reactions, neurological abnormalities, and hearing loss may occur, and any unusual symptoms should be reported to medical professionals immediately. Dizziness, vision impairment, and hearing loss may occur, and caution is advised when driving or operating machinery. Women who are pregnant or may become pregnant should not take this medication, and effective contraceptive measures must be used after taking the drug. Breastfeeding women should also discontinue nursing if taking this drug. Caution is advised when administering to children or the elderly, only using when the benefits outweigh the risks. In cases of overdose, as there is no specific antidote, treatment should be symptomatic, and this drug is not removed by hemodialysis. Keep this medicine out of reach of children and store in the original container to prevent misuse or deterioration of quality.

• Headache
• nausea
• abdominal pain
• rhinitis
• sinusitis
• upper respiratory infection
• leukopenia
• hypersensitivity
• taste disorder
• sensory impairment

This drug should be stored in a tightly sealed container to prevent air exposure and at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the effectiveness and prevent deterioration of the drug.

Appearance

White or yellowish round film-coated tablets

Package unit

28 tablets/bottle, 100 tablets/bottle